日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.

与疾病相关的 MRE11 变体的差异表达揭示了不同的表型结果

DeFoer McKenna B, Mostafa Ahmed M, Hartlerode Andrea J, Orban Steven K, McDonough Keegan, Quirk Sophie, Ferguson Brianna K L, Ferguson David O, Sekiguchi JoAnn M

Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.

MRE11 水平降低会导致与毛细血管扩张性共济失调样疾病不同的疾病表型

Hartlerode Andrea J, Mostafa Ahmed M, Orban Steven K, Benedeck Rachel, Campbell Koral, Hoenerhoff Mark J, Ferguson David O, Sekiguchi JoAnn M

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.

MRE11 GAR 基序调节 DNA 双链断裂处理和 ATR 激活

Yu Zhenbao, Vogel Gillian, Coulombe Yan, Dubeau Danielle, Spehalski Elizabeth, Hébert Josée, Ferguson David O, Masson Jean Yves, Richard Stéphane

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Mre11通过与CDK2相互作用来调控CtIP依赖的双链断裂修复。

Buis, Jeffrey; Stoneham, Trina; Spehalski, Elizabeth; Ferguson, David O

Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus

致癌性Myc易位与免疫球蛋白重链基因座的染色体位置和方向无关。

Spehalski, Elizabeth; Kovalchuk, Alexander L; Collins, John T; Liang, Genqing; Dubois, Wendy; Morse, Herbert C 3rd; Ferguson, David O; Casellas, Rafael; Dunnick, Wesley A

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability

聚谷氨酰胺扩增疾病蛋白会螯合 PTIP,从而减弱 DNA 修复并增加基因组不稳定性。

Xiao, Hong; Yu, Zhigang; Wu, Yipin; Nan, John; Merry, Diane E; Sekiguchi, JoAnn M; Ferguson, David O; Lieberman, Andrew P; Dressler, Gregory R

Chfr and RNF8 synergistically regulate ATM activation

Chfr 和 RNF8 协同调节 ATM 激活

Wu, Jiaxue; Chen, Yibin; Lu, Lin-Yu; Wu, Yipin; Paulsen, Michelle T; Ljungman, Mats; Ferguson, David O; Yu, Xiaochun

Multiple functions of MRN in end-joining pathways during isotype class switching

MRN在同型转换过程中末端连接通路中的多种功能

Dinkelmann, Maria; Spehalski, Elizabeth; Stoneham, Trina; Buis, Jeffrey; Wu, Yipin; Sekiguchi, JoAnn M; Ferguson, David O

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.

Mre11核酸酶活性在DNA修复和基因组稳定性中起着至关重要的作用,这与ATM激活不同

Buis Jeffrey, Wu Yipin, Deng Yibin, Leddon Jennifer, Westfield Gerwin, Eckersdorff Mark, Sekiguchi Joann M, Chang Sandy, Ferguson David O

The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells

Polycomb蛋白EZH2会损害乳腺上皮细胞的DNA修复。

Zeidler, Michael; Varambally, Sooryanarayana; Cao, Qi; Chinnaiyan, Arul M; Ferguson, David O; Merajver, Sofia D; Kleer, Celina G