日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation

神经退行性疾病风险变异促进溶酶体TMEM106B原纤维的积累。

Replogle, John Michael; Marks, Jordan D; Fernandez, Martin G; Yuan, Hebao; Yu, Dahyun; Winters, Elizabeth; Jawahar, Vidhya Maheswari; Deshmukh, Rishi; Sutanto, Renaldo; Kowal, Isabelle; Frankenfield, Ashley; Shi, Rachel; Carlomagno, Yari; Jansen-West, Karen; Todd, Tiffany W; Kopach, Andrii; Sandra Ndayambaje, Iradukunda; Qi, Yue A; Shantaraman, Ananth; Pozo-Cabanell, Ignacio; Sheth, Udit; Yue, Mei; Duong, Duc; Ferguson, Shawn M; Bennett, David A; Damme, Markus; Boeve, Brad F; Day, Gregory S; Kellman, Benjamin; Skarnes, William C; Petersen, Ronald C; Josephs, Keith A; Graff-Radford, Neill R; McDonough, Justin A; Prudencio, Mercedes; Barmada, Sami J; Zhang, Yongjie; Hao, Ling; DeTure, Michael; Rawlinson, Bailey; Engelberg-Cook, Erica; Casey, Monica Castanedes; Perez, Nathan; Dickson, Dennis W; Wingo, Aliza; Liu, Yue; Seyfried, Nicholas T; Wingo, Thomas S; Mosalaganti, Shyamal; Petrucelli, Leonard; Ward, Michael E

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage.

桥状脂质转运蛋白 VPS13C/PARK23 在溶酶体损伤后介导内质网-溶酶体接触

Wang Xinbo, Xu Peng, Bentley-DeSousa Amanda, Hancock-Cerutti William, Cai Shujun, Johnson Benjamin T, Tonelli Francesca, Shao Lin, Talaia Gabriel, Alessi Dario R, Ferguson Shawn M, De Camilli Pietro

Derailed degradation: LRRK2-dependent exocytosis in Parkinson's disease

降解受阻:帕金森病中LRRK2依赖性胞吐作用

Ferguson, Shawn M

A STING-CASM-GABARAP pathway activates LRRK2 at lysosomes

STING-CASM-GABARAP 通路激活溶酶体中的 LRRK2

Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson, Shawn M Ferguson

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses

LRRK2整合Rab和GABARAP的相互作用,以感知和响应不同的溶酶体应激。

Clegg, Devin; Bentley-DeSousa, Amanda; Roczniak-Ferguson, Agnes; Ferguson, Shawn M

Lysosomal swelling triggers LRRK2 activity

溶酶体肿胀触发LRRK2活性

Malankhanova, Tuyana; Liu, Zhiyong; Strader, Samuel; Wang, Weiping; Sung, Kiwoon; Li, Zhong; Ferguson, Shawn M; West, Andrew B

Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

PQLC2氨基酸转运蛋白在溶酶体感知阳离子氨基酸中发挥受体样作用

Talaia, Gabriel; Amick, Joseph; Ferguson, Shawn M

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

JIP3和JIP4在促进人iPSC衍生神经元中溶酶体的轴突运输中发挥重叠作用

Gowrishankar, Swetha; Lyons, Lila; Rafiq, Nisha Mohd; Roczniak-Ferguson, Agnes; De Camilli, Pietro; Ferguson, Shawn M

Coordination of Rheb lysosomal membrane interactions with mTORC1 activation

Rheb溶酶体膜相互作用与mTORC1激活的协调

Angarola, Brittany; Ferguson, Shawn M

Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis

人类TDP-43在调节细胞和细胞器稳态中的多效性需求

Roczniak-Ferguson, Agnes; Ferguson, Shawn M