日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models

微管不稳定剂 Eribulin 与 STING 激动剂协同作用,增强三阴性乳腺癌模型中的抗肿瘤功效

Leila Takahashi-Ruiz, Charles S Fermaintt, Nancy J Wilkinson, Peter Y W Chan, Susan L Mooberry, April L Risinger

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Gatorbulin-1 是一种独特的环状缩肽化学类型,靶向第七个微管蛋白药理学位点。

Matthew, Susan; Chen, Qi-Yin; Ratnayake, Ranjala; Fermaintt, Charles S; Lucena-Agell, Daniel; Bonato, Francesca; Prota, Andrea E; Lim, Seok Ting; Wang, Xiaomeng; Díaz, J Fernando; Risinger, April L; Paul, Valerie J; Oliva, Maria Ángela; Luesch, Hendrik

Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

Eribulin 通过线粒体 DNA 在细胞质中的积累激活 cGAS-STING 通路

Charles S Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L Mooberry, April L Risinger

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential

芫花甲素是一种具有免疫原性潜力的三阴性乳腺癌 Basal-Like 2 亚型的强效选择性抑制剂

Charles S Fermaintt, Thilini Peramuna, Shengxin Cai, Leila Takahashi-Ruiz, Jacob Nathaniel Essif, Corena V Grant, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz, April L Risinger

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

与自身免疫相关的生物活性哺乳动物二糖可激活 STING-TBK1 依赖性免疫反应

Charles S Fermaintt, Kanae Sano, Zhida Liu, Nozomi Ishii, Junichi Seino, Nicole Dobbs, Tadashi Suzuki, Yang-Xin Fu, Mark A Lehrman, Ichiro Matsuo, Nan Yan

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis

哺乳动物 STT3A/B 寡糖基转移酶将转运蛋白上的 N-糖基化与脂质连接寡糖水解分离

Hua Lu, Charles S Fermaintt, Natalia A Cherepanova, Reid Gilmore, Nan Yan, Mark A Lehrman

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice

DNase 活性 TREX1 移码突变体在小鼠中诱发血清学自身免疫

Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L Kovalchuk, Parul H Kothari, Charles S Fermaintt, John P Atkinson, Fred W Perrino, Nan Yan, Herbert C Morse 3rd0

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

TREX1 C 末端的有丝分裂磷酸化破坏了 TREX1 对寡糖基转移酶复合物的调节

Martin Kucej, Charles S Fermaintt, Kun Yang, Ricardo A Irizarry-Caro, Nan Yan

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

胞浆核酸酶 TREX1 调节寡糖基转移酶活性(不依赖于核酸酶活性)以抑制免疫激活

Maroof Hasan, Charles S Fermaintt, Ningguo Gao, Tomomi Sakai, Takuya Miyazaki, Sixin Jiang, Quan-Zhen Li, John P Atkinson, Herbert C Morse 3rd, Mark A Lehrman, Nan Yan

Cellular metabolism of unnatural sialic acid precursors

非天然唾液酸前体的细胞代谢

Nam D Pham, Charles S Fermaintt, Andrea C Rodriguez, Janet E McCombs, Nicole Nischan, Jennifer J Kohler