日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells

一类针对 SRSF10 并促进 p53 介导的人类结直肠癌细胞细胞毒性的新型抑制剂

Muhammad Sohail, Lulzim Shkreta, Johanne Toutant, Safwat Rabea, Jean-Philippe Babeu, Caroline Huard, Jasmin Coulombe-Huntington, Aurélie Delannoy, Morgane Placet, Sameh Geha, Fernand-Pierre Gendron, François Boudreau, Mike Tyers, David S Grierson, Benoit Chabot

The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration

P2Y6 受体通过 Gαq /Ca2+ /PKCα 和 Gα13 /ROCK 通路发出信号,驱动膜突起的形成并控制细胞迁移

Mélissa Girard, Steve Dagenais Bellefeuille, Émilie Eiselt, Rebecca Brouillette, Morgane Placet, Guillaume Arguin, Jean-Michel Longpré, Philippe Sarret, Fernand-Pierre Gendron

The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis

P2X7 受体表达的丧失导致肠道葡萄糖转运增加和肝脏脂肪变性

Guillaume Arguin, Jean-François Bourzac, Morgane Placet, Caroline M Molle, Michel Paquette, Jean-François Beaudoin, Jacques A Rousseau, Roger Lecomte, Mélanie Plourde, Fernand-Pierre Gendron

Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury

Gata4 对于维持上皮损伤后的肠屏障功能和粘膜完整性至关重要

David Lepage, Élise Bélanger, Christine Jones, Sarah Tremblay, Joannie M Allaire, Joannie Bruneau, Claude Asselin, Nathalie Perreault, Alfredo Menendez, Fernand-Pierre Gendron, Francois Boudreau

Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs

腺苷 5'-三磷酸上调结直肠癌细胞中的多药耐药相关蛋白 2 表达并增强其对化疗药物的存活率

Valérie Vinette, Morgane Placet, Guillaume Arguin, Fernand-Pierre Gendron

P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells

NF-κB 增加 P2Y2 受体转录,并刺激环氧合酶-2 表达和肠上皮细胞释放 PGE2

Emilie Degagné, Djordje M Grbic, Andrée-Anne Dupuis, Elise G Lavoie, Christine Langlois, Nishant Jain, Gary A Weisman, Jean Sévigny, Fernand-Pierre Gendron