Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
肺炎溶素激活NLRP3炎症小体,并促进促炎细胞因子的产生,而这一过程独立于TLR4。
期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1001191
McNeela, Edel A; Burke, Aine; Neill, Daniel R; Baxter, Cathy; Fernandes, Vitor E; Ferreira, Daniela; Smeaton, Sarah; El-Rachkidy, Rana; McLoughlin, Rachel M; Mori, Andres; Moran, Barry; Fitzgerald, Katherine A; Tschopp, Jurg; Pétrilli, Virginie; Andrew, Peter W; Kadioglu, Aras; Lavelle, Ed C
肺炎
炎症
炎性小体
炎症/感染
LRP3
TLR4
NLRP3
细胞生物学
炎性小体
免疫/内分泌