日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protocol for high-throughput cloning, expression, purification, and evaluation of bispecific antibodies

双特异性抗体的高通量克隆、表达、纯化和评估方案

Danqing Li, Alexander C Partin, Liangjun Zhao, Irwin Chen, Mark L Michaels, Zhulun Wang, Fernando Garces, Danyang Gong, Timothy P Riley

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

通过结构引导设计增强 SARS-CoV-2 刺突蛋白的融合前构象稳定性

Timothy P Riley, Hui-Ting Chou, Ruozhen Hu, Krzysztof P Bzymek, Ana R Correia, Alexander C Partin, Danqing Li, Danyang Gong, Zhulun Wang, Xinchao Yu, Paolo Manzanillo, Fernando Garces

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

通过压力抗体-靶标复合物的尺寸排阻色谱法鉴定关键化学修饰并进行互补位定位

Pavel Bondarenko, Andrew C Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J Semin, Margaret S Ricci

Rational selection of building blocks for the assembly of bispecific antibodies

双特异性抗体组装构件的合理选择

Danyang Gong, Timothy P Riley, Krzysztof P Bzymek, Ana R Correia, Danqing Li, Christopher Spahr, John H Robinson, Ryan B Case, Zhulun Wang, Fernando Garces

Next generation Fc scaffold for multispecific antibodies

用于多特异性抗体的下一代Fc支架

Bram Estes, Athena Sudom, Danyang Gong, Douglas A Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P Riley, Stone D-H Shi, Jun Zhang, Fernando Garces, Zhulun Wang

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

基于 M 组共识序列的稳定 HIV-1 包膜三聚体的结构和免疫原性

Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J M Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariël

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

高效的单链断裂修复需要XRCC1中心BRCT结构域同时结合聚(ADP-核糖)和DNA。

Luis M Polo,Yingqi Xu,Peter Hornyak,Fernando Garces,Zhihong Zeng,Richard Hailstone,Steve J Matthews,Keith W Caldecott,Antony W Oliver,Laurence H Pearl

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

黑猩猩SIV包膜三聚体:结构及其作为HIV疫苗模板的应用

Raiees Andrabi ,Jesper Pallesen ,Joel D Allen ,Ge Song ,Jinsong Zhang ,Natalia de Val ,Gavin Gegg ,Katelyn Porter ,Ching-Yao Su ,Matthias Pauthner ,Amanda Newman ,Hilary Bouton-Verville ,Fernando Garces ,Ian A Wilson ,Max Crispin ,Beatrice H Hahn ,Barton F Haynes ,Laurent Verkoczy ,Andrew B Ward ,Dennis R Burton

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

螺旋-卷曲转变处的甘氨酸取代有助于稳定型C亚型HIV包膜糖蛋白的结构解析

Javier Guenaga ,Fernando Garces ,Natalia de Val ,Robyn L Stanfield ,Viktoriya Dubrovskaya ,Brett Higgins ,Barbara Carrette ,Andrew B Ward ,Ian A Wilson ,Richard T Wyatt

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

类似天然的 HIV-1 包膜三聚体的设计和晶体结构,可在体内与多种广泛中和抗体前体结合

Max Medina-Ramírez, Fernando Garces, Amelia Escolano, Patrick Skog, Steven W de Taeye, Ivan Del Moral-Sanchez, Andrew T McGuire, Anila Yasmeen, Anna-Janina Behrens, Gabriel Ozorowski, Tom L G M van den Kerkhof, Natalia T Freund, Pia Dosenovic, Yuanzi Hua, Alexander D Gitlin, Albert Cupo, Patricia va