日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons.

C9orf72-ALS 突变导致 iNeurons 中基础线粒体自噬受损。

Lee James A K, Moutin Chloe, Granger Sarah, Roome Katie, Shaw Allan, Allen Scott P, Ferraiuolo Laura, Shaw Pamela J, Mortiboys Heather

Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice.

比较小鼠中采用不同中枢神经系统靶向递送方法后 AAV9 驱动的运动神经元转导情况。

Mortimer Alannah J, Sander Chiara F, Parmar Amisha R, Williams Ailsa J, Azzouz Mimoun, Hautbergue Guillaume M, Shaw Pamela J, Ferraiuolo Laura, Mead Richard J

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis

M102 可激活 NRF2 和 HSF1 转录因子通路,并在肌萎缩侧索硬化症的细胞和动物模型中发挥神经保护作用。

Keerie, Amy F; Martins, Raquel Rua; Allen, Chloe F; Bowden, Katie; Al Mashhadi, Sufana; Marlow, Thomas; Myszczynska, Monika; Thakur, Nikitha; Beal, Selina N; Shaw, Allan; Suresh, Shivani; McKinnon, Scott N; Cooper-Knock, Johnathan; West, Ryan J H; Bonsall, Sam; Daniel, Alex; Wells, Tyler; Kumar, Vedanth; Ellis, Brittany C S; Higgins, Maureen; Dinkova-Kostova, Albena T; Shelkovnikova, Tatyana A; Kalfus, Ira N; Shan, Ning; Shaw, Pamela J; Ferraiuolo, Laura; Mead, Richard J

Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer's disease astrocytes.

增加己糖激酶 1 的表达可以改善散发性阿尔茨海默病星形胶质细胞中观察到的线粒体和糖酵解功能缺陷

Bell Simon M, Wareing Hollie, Capriglia Francesco, Hughes Rachel, Barnes Katy, Hamshaw Alexander, Adair Liam, Shaw Allan, Olejnik Alicja, De Suman, New Elizabeth, Shaw Pamela J, De Marco Matteo, Venneri Annalena, Blackburn Daniel J, Ferraiuolo Laura, Mortiboys Heather

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

RuvBL1/2 可降低多种 C9orf72-ALS/FTD 模型中的毒性二肽重复蛋白负荷

Webster Christopher P, Hall Bradley, Crossley Olivia M, Dauletalina Dana, King Marianne, Lin Ya-Hui, Castelli Lydia M, Yang Zih-Liang, Coldicott Ian, Kyrgiou-Balli Ergita, Higginbottom Adrian, Ferraiuolo Laura, De Vos Kurt J, Hautbergue Guillaume M, Shaw Pamela J, West Ryan Jh, Azzouz Mimoun

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

评估源自人类运动神经元低甲基化DNA特征的肌萎缩侧索硬化症生物标志物

Harvey, Calum; Nowak, Alicja; Zhang, Sai; Moll, Tobias; Weimer, Annika K; Barcons, Aina Mogas; Dos Santos Souza, Cleide; Ferraiuolo, Laura; Kenna, Kevin; Zaitlen, Noah; Caggiano, Christa; Shaw, Pamela J; Snyder, Michael P; Mill, Jonathan; Hannon, Eilis; Cooper-Knock, Johnathan

Editorial: The role of glial cells in neurodegeneration

社论:神经胶质细胞在神经退行性疾病中的作用

Pasinelli, Piera; Meyer, Kathrin; Ferraiuolo, Laura; Culibrk, Robert A; Sattler, Rita

Blood-Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders

血脑屏障破坏及其在神经发育和神经退行性疾病中的作用

Aragón-González, Ana; Shaw, Pamela J; Ferraiuolo, Laura

DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity

DNA损伤是ALS神经退行性变的一种机制,也是星形胶质细胞毒性的一个促成因素。

Kok, Jannigje Rachel; Palminha, Nelma M; Dos Santos Souza, Cleide; El-Khamisy, Sherif F; Ferraiuolo, Laura

Emerging Mechanisms Underpinning Neurophysiological Impairments in C9ORF72 Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

C9ORF72重复扩增介导的肌萎缩侧索硬化症/额颞叶痴呆症中神经生理功能障碍的新兴机制

Pasniceanu, Iris-Stefania; Atwal, Manpreet Singh; Souza, Cleide Dos Santos; Ferraiuolo, Laura; Livesey, Matthew R