日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性

Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi

Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers

Sotorasib 是一种泛 RASG12C 抑制剂,能够促进 NRASG12C 癌症的临床反应

Douglas A Rubinson #, Noritaka Tanaka #, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran

Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

FGFR2 变异胆管癌对 FGFR 抑制剂的临床耐药机制概况

Qibiao Wu, Haley Ellis, Giulia Siravegna, Alexa G Michel, Bryanna L Norden, Ferran Fece de la Cruz, Eranga Roshan Balasooriya, Yuanli Zhen, Vanessa S Silveira, Jianwe Che, Ryan B Corcoran, Nabeel Bardeesy

Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition

垂直通路抑制克服了对 KRASG12C 抑制的适应性反馈抵抗

Meagan B Ryan, Ferran Fece de la Cruz, Sarah Phat, David T Myers, Edmond Wong, Heather A Shahzade, Catriona B Hong, Ryan B Corcoran

Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

RAS-MAPK 通路同时发生的改变限制了 MET 外显子 14 跳跃突变阳性肺癌患者对 MET 抑制剂治疗的反应

Julia K Rotow, Philippe Gui, Wei Wu, Victoria M Raymond, Richard B Lanman, Frederic J Kaye, Nir Peled, Ferran Fece de la Cruz, Brandon Nadres, Ryan B Corcoran, Iwei Yeh, Boris C Bastian, Petr Starostik, Kimberly Newsom, Victor R Olivas, Alexander M Wolff, James S Fraser, Eric A Collisson, Caroline E

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

液体活检与组织活检在检测胃肠道癌症获得性耐药性和肿瘤异质性方面的比较

Parikh, Aparna R; Leshchiner, Ignaty; Elagina, Liudmila; Goyal, Lipika; Levovitz, Chaya; Siravegna, Giulia; Livitz, Dimitri; Rhrissorrakrai, Kahn; Martin, Elizabeth E; Van Seventer, Emily E; Hanna, Megan; Slowik, Kara; Utro, Filippo; Pinto, Christopher J; Wong, Alicia; Danysh, Brian P; de la Cruz, Ferran Fece; Fetter, Isobel J; Nadres, Brandon; Shahzade, Heather A; Allen, Jill N; Blaszkowsky, Lawrence S; Clark, Jeffrey W; Giantonio, Bruce; Murphy, Janet E; Nipp, Ryan D; Roeland, Eric; Ryan, David P; Weekes, Colin D; Kwak, Eunice L; Faris, Jason E; Wo, Jennifer Y; Aguet, François; Dey-Guha, Ipsita; Hazar-Rethinam, Mehlika; Dias-Santagata, Dora; Ting, David T; Zhu, Andrew X; Hong, Theodore S; Golub, Todd R; Iafrate, A John; Adalsteinsson, Viktor A; Bardelli, Alberto; Parida, Laxmi; Juric, Dejan; Getz, Gad; Corcoran, Ryan B

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma

TAS-120 可克服 FGFR2 融合阳性肝内胆管癌患者对 ATP 竞争性 FGFR 抑制剂的耐药性

Lipika Goyal #, Lei Shi #, Leah Y Liu #, Ferran Fece de la Cruz #, Jochen K Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, Giulia Siravegna, Raymond W S Ng, Phuong Vu, Krushna C Patra, Supriya K Saha, Raul N Uppot, Ron Arellano, Stephanie Reyes, Takeshi Sagara, Sachie Otsuki, Brand

Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer

VWA2 的表观遗传和转录失调与结直肠癌中 MYC 驱动的致癌程序有关

Beatriz González, Ferran Fece de la Cruz, Johanna Kristina Samuelsson, Andreu Alibés, Sergio Alonso

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated

MEK 抑制剂可阻断毛细血管扩张性共济失调症突变的肺癌生长

Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K Muellner, Zsuzsanna Bago-Horvath, Eric B Haura, Joanna I Loizou, Sebastian M B Nijman

A reversible gene trap collection empowers haploid genetics in human cells

可逆基因陷阱集合增强了人类细胞中的单倍体遗传学

Tilmann Bürckstümmer, Carina Banning, Philipp Hainzl, Richard Schobesberger, Claudia Kerzendorfer, Florian M Pauler, Doris Chen, Nicole Them, Fiorella Schischlik, Manuele Rebsamen, Michal Smida, Ferran Fece de la Cruz, Ana Lapao, Melissa Liszt, Benjamin Eizinger, Philipp M Guenzl, Vincent A Blomen,