HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
尽管接受了有效的抗逆转录病毒疗法，但 CD4/CD8 比率低的 HIV 感染者表现出 T 细胞亚群改变、CD8+ T 细胞活化增强以及非艾滋病发病率和死亡率增加
期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1004078
Serrano-Villar Sergio, Sainz Talia, Lee Sulggi A, Hunt Peter W, Sinclair Elizabeth, Shacklett Barbara L, Ferre April L, Hayes Timothy L, Somsouk Ma, Hsue Priscilla Y, Van Natta Mark L, Meinert Curtis L, Lederman Michael M, Hatano Hiroyu, Jain Vivek, Huang Yong, Hecht Frederick M, Martin Jeffrey N, McCune Joseph M, Moreno Santiago, Deeks Steven G
