日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

吡咯基二氢乳清酸脱氢酶抑制剂系列先导化合物的优化及其在疟疾治疗中的应用

Kokkonda Sreekanth, Deng Xiaoyi, White Karen L, El Mazouni Farah, White John, Shackleford David M, Katneni Kasiram, Chiu Francis C K, Barker Helena, McLaren Jenna, Crighton Elly, Chen Gong, Angulo-Barturen Inigo, Jimenez-Diaz Maria Belen, Ferrer Santiago, Huertas-Valentin Leticia, Martinez-Martinez Maria Santos, Lafuente-Monasterio Maria Jose, Chittimalla Rajesh, Shahi Shatrughan P, Wittlin Sergio, Waterson David, Burrows Jeremy N, Matthews Dave, Tomchick Diana, Rathod Pradipsinh K, Palmer Michael J, Charman Susan A, Phillips Margaret A

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

确定 GSK3186899/DDD853651 为治疗内脏利什曼病的临床前开发候选药物

Thomas, Michael G; De Rycker, Manu; Ajakane, Myriam; Albrecht, Sébastian; Álvarez-Pedraglio, Ana Isabel; Boesche, Markus; Brand, Stephen; Campbell, Lorna; Cantizani-Perez, Juan; Cleghorn, Laura A T; Copley, Royston C B; Crouch, Sabrinia D; Daugan, Alain; Drewes, Gerard; Ferrer, Santiago; Ghidelli-Disse, Sonja; Gonzalez, Silvia; Gresham, Stephanie L; Hill, Alan P; Hindley, Sean J; Lowe, Rhiannon M; MacKenzie, Claire J; MacLean, Lorna; Manthri, Sujatha; Martin, Franck; Miguel-Siles, Juan; Nguyen, Van Loc; Norval, Suzanne; Osuna-Cabello, Maria; Woodland, Andrew; Patterson, Stephen; Pena, Imanol; Quesada-Campos, Maria Teresa; Reid, Iain H; Revill, Charlotte; Riley, Jennifer; Ruiz-Gomez, Jose Ramon; Shishikura, Yoko; Simeons, Frederick R C; Smith, Alasdair; Smith, Victoria C; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Underwood, Tim; Gray, David W; Fiandor, Jose M; Gilbert, Ian H; Wyatt, Paul G; Read, Kevin D; Miles, Timothy J

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis

谷胱甘肽生物合成在内皮功能障碍和纤维化中的作用

Cristina Espinosa-Díez ,Verónica Miguel ,Susana Vallejo ,Francisco J Sánchez ,Elena Sandoval ,Eva Blanco ,Pablo Cannata ,Concepción Peiró ,Carlos F Sánchez-Ferrer ,Santiago Lamas

A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers

在健康志愿者中开展抗疟疾药物GSK3191607的人体微剂量研究

Okour, Malek; Derimanov, Geo; Barnett, Rodger; Fernandez, Esther; Ferrer, Santiago; Gresham, Stephanie; Hossain, Mohammad; Gamo, Francisco-Javier; Koh, Gavin; Pereira, Adrian; Rolfe, Katie; Wong, Deborah; Young, Graeme; Rami, Harshad; Haselden, John

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

新型抗疟化合物ACT-451840的特性研究:活性和剂量-疗效模型的临床前评估

Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnädig, Nina F; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J; Ng, Caroline L; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N; Weller, Thomas; Fischli, Walter; Fidock, David A; Clozel, Martine; Wittlin, Sergio

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

将小鼠和人类恶性疟原虫感染模型联系起来,构建抗疟药物研发的转化路径

McCarthy, James S; Marquart, Louise; Sekuloski, Silvana; Trenholme, Katharine; Elliott, Suzanne; Griffin, Paul; Rockett, Rebecca; O'Rourke, Peter; Sloots, Theo; Angulo-Barturen, Iñigo; Ferrer, Santiago; Jiménez-Díaz, María Belén; Martínez, María-Santos; Hooft van Huijsduijnen, Rob; Duparc, Stephan; Leroy, Didier; Wells, Timothy N C; Baker, Mark; Möhrle, Jörg J

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

组蛋白甲基转移酶抑制剂是口服生物利用度高、起效迅速的分子,对引起人类疟疾的不同疟原虫种类均有活性。

Malmquist, Nicholas A; Sundriyal, Sandeep; Caron, Joachim; Chen, Patty; Witkowski, Benoit; Menard, Didier; Suwanarusk, Rossarin; Renia, Laurent; Nosten, Francois; Jiménez-Díaz, María Belén; Angulo-Barturen, Iñigo; Santos Martínez, María; Ferrer, Santiago; Sanz, Laura M; Gamo, Francisco-Javier; Wittlin, Sergio; Duffy, Sandra; Avery, Vicky M; Ruecker, Andrea; Delves, Michael J; Sinden, Robert E; Fuchter, Matthew J; Scherf, Artur

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives

小分子抗疟药案例研究:2-氨基-1-苯基乙醇(APE)衍生物

Chaparro, María J; Vidal, Jaume; Angulo-Barturen, Iñigo; Bueno, José M; Burrows, Jeremy; Cammack, Nicholas; Castañeda, Pablo; Colmenarejo, Gonzalo; Coterón, José M; de Las Heras, Laura; Fernández, Esther; Ferrer, Santiago; Gabarró, Raquel; Gamo, Francisco J; García, Mercedes; Jiménez-Díaz, María B; Lafuente, María J; León, María L; Martínez, María S; Minick, Douglas; Prats, Sara; Puente, Margarita; Rueda, Lourdes; Sandoval, Elena; Santos-Villarejo, Angel; Witty, Michael; Calderón, Félix

Quinolone-3-diarylethers: a new class of antimalarial drug

喹诺酮-3-二芳基醚:一类新型抗疟药

Nilsen, Aaron; LaCrue, Alexis N; White, Karen L; Forquer, Isaac P; Cross, Richard M; Marfurt, Jutta; Mather, Michael W; Delves, Michael J; Shackleford, David M; Saenz, Fabian E; Morrisey, Joanne M; Steuten, Jessica; Mutka, Tina; Li, Yuexin; Wirjanata, Grennady; Ryan, Eileen; Duffy, Sandra; Kelly, Jane Xu; Sebayang, Boni F; Zeeman, Anne-Marie; Noviyanti, Rintis; Sinden, Robert E; Kocken, Clemens H M; Price, Ric N; Avery, Vicky M; Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Ferrer, Santiago; Herreros, Esperanza; Sanz, Laura M; Gamo, Francisco-Javier; Bathurst, Ian; Burrows, Jeremy N; Siegl, Peter; Guy, R Kiplin; Winter, Rolf W; Vaidya, Akhil B; Charman, Susan A; Kyle, Dennis E; Manetsch, Roman; Riscoe, Michael K

A new in vivo screening paradigm to accelerate antimalarial drug discovery

一种加速抗疟药物发现的新型体内筛选范式

Jiménez-Díaz, María Belén; Viera, Sara; Ibáñez, Javier; Mulet, Teresa; Magán-Marchal, Noemí; Garuti, Helen; Gómez, Vanessa; Cortés-Gil, Lorena; Martínez, Antonio; Ferrer, Santiago; Fraile, María Teresa; Calderón, Félix; Fernández, Esther; Shultz, Leonard D; Leroy, Didier; Wilson, David M; García-Bustos, José Francisco; Gamo, Francisco Javier; Angulo-Barturen, Iñigo