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Pharmacokinetics of Bocidelpar, ASP0367, in Renal and Hepatic Impairment: Results From Two Phase 1 Studies

Bocidelpar（ASP0367）在肾功能和肝功能受损患者中的药代动力学：两项 I 期研究的结果

期刊:Cts-Clinical and Translational Science

Iwai, Megumi; Heo, Nakyo; Hashimoto, Kentaro; Guro, Sayuri; Moy, Selina; Spence, Anna; Wojtkowski, Tomasz; Benner, Lauren; Helmick, Melanie; Zhu, Tong; Ferslew, Brian C

发表日期：2025

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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites

一项针对对屋尘螨过敏的成年人的皮内注射DNA疫苗ASP2390的安全性、耐受性和有效性的I期研究

期刊:Journal of Allergy and Clinical Immunology Global

影响因子:

doi:10.1016/j.jacig.2025.100404

Kayser, Thomas; Smulders, Ronald; Kusawake, Tomohiro; Wambre, Erik; Chichili, Gurunadh R; Blauwet, Mary B; Spence, Anna; Patton, Melanie; Tabash, Rima; DeBerg, Hannah A; Khosa, Sugandhika; Badorrek, Philipp; Hohlfeld, Jens M; Ferslew, Brian C

发表日期：2025

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Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy

接受口服免疫疗法的花生过敏患者体内，抗原特异性T细胞的轨迹各不相同。

期刊:Journal of Allergy and Clinical Immunology

影响因子:11.2

doi:10.1016/j.jaci.2023.03.020

Calise, Justine; DeBerg, Hannah; Garabatos, Nahir; Khosa, Sugandhika; Bajzik, Veronique; Calderon, Lorena Botero; Aldridge, Kelly; Rosasco, Mario; Ferslew, Brian C; Zhu, Tong; Smulders, Ronald; Wheatley, Lisa M; Laidlaw, Tanya M; Qin, Tielin; Chichili, Gurunadh R; Adelman, Daniel C; Farrington, Mary; Robinson, David; Jeong, David; Jones, Stacie M; Sanda, Srinath; Larson, David; Kwok, William W; Baloh, Carolyn; Nepom, Gerald T; Wambre, Erik

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

12-羟基在非结合型C24胆汁酸负离子碎片化中的关键作用

期刊:Analytical Chemistry

影响因子:6.7

doi:10.1021/acs.analchem.6b00573

Lan, Ke; Su, Mingming; Xie, Guoxiang; Ferslew, Brian C; Brouwer, Kim L R; Rajani, Cynthia; Liu, Changxiao; Jia, Wei

发表日期：2016

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Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

非酒精性脂肪性肝炎中细胞色素 P450 环氧二十碳酸途径的特征分析

期刊:Prostaglandins & Other Lipid Mediators

影响因子:2.5

doi:10.1016/j.prostaglandins.2016.07.002

Wells Michael A, Vendrov Kimberly C, Edin Matthew L, Ferslew Brian C, Zha Weibin, Nguyen Bobbie K H, Church Rachel J, Lih Fred B, DeGraff Laura M, Brouwer Kim L R, Barritt A Sidney 4th, Zeldin Darryl C, Lee Craig R

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

在生理相关的模型——夹层培养的大鼠肝细胞中鉴定肝磷脂沉积症诱导剂，揭示了阴离子探针底物的基底外侧摄取和胆汁排泄的改变。

期刊:Toxicological Sciences

影响因子:4.1

doi:10.1093/toxsci/kfu033

Ferslew, Brian C; Brouwer, Kim L R

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

肝脏基底外侧膜外排对瑞舒伐他汀的体内分布有显著贡献 II：大鼠离体灌注肝脏中基底外侧膜、胆汁和代谢清除途径的肝脏消除特征

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1124/jpet.113.208314

Pfeifer, Nathan D; Bridges, Arlene S; Ferslew, Brian C; Hardwick, Rhiannon N; Brouwer, Kim L R

New Insights Into Hepatic Impairment (HI) Trials

肝功能损害（HI）试验的新见解

Pharmacokinetics of Bocidelpar, ASP0367, in Renal and Hepatic Impairment: Results From Two Phase 1 Studies

Bocidelpar（ASP0367）在肾功能和肝功能受损患者中的药代动力学：两项 I 期研究的结果

Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites

一项针对对屋尘螨过敏的成年人的皮内注射DNA疫苗ASP2390的安全性、耐受性和有效性的I期研究

Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy

接受口服免疫疗法的花生过敏患者体内，抗原特异性T细胞的轨迹各不相同。

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

12-羟基在非结合型C24胆汁酸负离子碎片化中的关键作用

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

非酒精性脂肪性肝炎中细胞色素 P450 环氧二十碳酸途径的特征分析

Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates

在生理相关的模型——夹层培养的大鼠肝细胞中鉴定肝磷脂沉积症诱导剂，揭示了阴离子探针底物的基底外侧摄取和胆汁排泄的改变。

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

肝脏基底外侧膜外排对瑞舒伐他汀的体内分布有显著贡献 II：大鼠离体灌注肝脏中基底外侧膜、胆汁和代谢清除途径的肝脏消除特征