日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease

小而可扩散的聚集体、斑块、缠结和动态平衡:解开阿尔茨海默病之谜

Fertan, Emre; Meisl, Georg; Klenerman, David

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab 优先与阿尔茨海默病早期存在的较小聚集体结合

Fertan Emre, Lam Jeff Y L, Albertini Giulia, Dewilde Maarten, Wu Yunzhao, Akingbade Oluwatomi E S, Böken Dorothea, English Elizabeth A, De Strooper Bart, Klenerman David

Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform

基于 Simoa 平台的超灵敏蛋白聚集体定量检测方法用于神经退行性疾病的研究

Dorothea Böken ,Zengjie Xia ,Jeff Y L Lam ,Emre Fertan ,Yunzhao Wu ,Elizabeth A English ,Juraj Konc ,Florence Layburn ,Gonçalo J L Bernardes ,Henrik Zetterberg ,Matthew R Cheetham ,David Klenerman

Correction to "Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform"

对“基于 Simoa 平台的神经退行性疾病超灵敏蛋白聚集体定量分析”一文的更正

Böken, Dorothea; Xia, Zengjie; Lam, Jeff Y L; Fertan, Emre; Wu, Yunzhao; English, Elizabeth A; Konc, Juraj; Layburn, Florence; Bernardes, Gonçalo J L; Zetterberg, Henrik; Cheetham, Matthew R; Klenerman, David

Detection of p53 aggregates in plasma of glioma patients.

检测胶质瘤患者血浆中的p53聚集体

Wu Yunzhao, Lam Jeff Y L, Pitoulias Matthaios, Böken Dorothea, Zhang Ziwei, Chintapalli Renuka, Fertan Emre, Xia Zengjie, Danial John S H, Tsang-Pells Gemma, Fysh Emily, Julian Linda, Brindle Kevin M, Mair Richard, Klenerman David

Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples

人类样本中与阿尔茨海默病相关的tau蛋白聚集体的单分子表征和超分辨率成像

Böken, Dorothea; Cox, Dezerae; Burke, Melanie; Lam, Jeff Y L; Katsinelos, Taxiarchis; Danial, John S H; Fertan, Emre; McEwan, William A; Rowe, James B; Klenerman, David

APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease

APP反义寡核苷酸可减少β-淀粉样蛋白聚集并挽救阿尔茨海默病中的内溶酶体功能障碍

Christy Hung ,Emre Fertan ,Frederick J Livesey ,David Klenerman ,Rickie Patani

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy

21号染色体三体脑类器官分泌与阿尔茨海默病相关的可溶性聚集体,这些聚集体可通过单分子荧光和超分辨率显微镜检测到。

Emre Fertan ,Dorothea Böken ,Aoife Murray ,John S H Danial ,Jeff Y L Lam ,Yunzhao Wu ,Pollyanna A Goh ,Ivan Alić ,Matthew R Cheetham ,Evgeniia Lobanova ,Yu P Zhang ,Dean Nižetić # ,David Klenerman #

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia

来自星形胶质细胞的APOE可恢复APOE缺陷型小胶质细胞中的阿尔茨海默病Aβ病理和DAM样反应

Pranav Preman ,Daan Moechars ,Emre Fertan ,Leen Wolfs ,Lutgarde Serneels ,Disha Shah ,Jochen Lamote ,Suresh Poovathingal ,An Snellinx ,Renzo Mancuso ,Sriram Balusu ,David Klenerman ,Amaia M Arranz ,Mark Fiers ,Bart De Strooper

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease

选择性抑制少突胶质细胞来源的β-淀粉样蛋白可挽救阿尔茨海默病中的神经元功能障碍

Rikesh M Rajani ,Robert Ellingford ,Mariam Hellmuth ,Samuel S Harris ,Orjona S Taso ,David Graykowski ,Francesca Kar Wey Lam ,Charles Arber ,Emre Fertan ,John S H Danial ,Matthew Swire ,Marcus Lloyd ,Tatiana A Giovannucci ,Mathieu Bourdenx ,David Klenerman ,Robert Vassar ,Selina Wray ,Carlo Sala Frigerio ,Marc Aurel Busche