日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL(Pro)

SARS-CoV-2 PL(Pro)片段抑制剂的发现

Wei, Qiangqiang; Taylor, Ashley J; Barmade, Mahesh Angadrao; Teuscher, Kevin B; Chowdhury, Somanath; Apakama, Chideraa; Anderson-Daniels, Jordan; Yongqing, Zhu; Schultz, David C; Rietz, Tyson A; South, Taylor M; Crow, Mackenzie M; Zhao, Bin; Amporndanai, Kangsa; Sensintaffar, John L; Phan, Jason; Cherry, Sara; Denison, Mark; Lee, Taekyu; Fesik, Stephen W

Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease

发现螺[色满-2,4'-哌啶]衍生物作为SARS-CoV-2木瓜蛋白酶样蛋白酶的不可逆抑制剂

Wei, Qiangqiang; Taylor, Ashley J; Miriyala, Nagaraju; Barmade, Mahesh A; Gentry, Zachary O; Anderson-Daniels, Jordan; Teuscher, Kevin B; Crow, Mackenzie M; Apakama, Chideraa; South, Taylor M; Rietz, Tyson A; Amporndanai, Kangsa; Phan, Jason; Sensintaffar, John L; Denison, Mark; Lee, Taekyu; Fesik, Stephen W

Identification of KLHL12 Ligands Using Fragment-Based Methods

利用基于片段的方法鉴定KLHL12配体

Waterson, Alex G; Vadukoot, Anish; Jana, Somnath; Cui, Jianwen; Luong, Kelvin; Rietz, Tyson A; Madrigal-Carrillo, Ezequiel Alejandro; Lehmann, Brian D; Sensintaffar, John L; Zhao, Bin; Amporndanai, Kangsa; Petros, Zoe A; Scaggs, William Rush; Chacon Simon, Selena; Vekariya, Rakesh H; Kim, Kwangho; Thangaraj, Manikandan; Christov, Plamen P; South, Taylor M; Sai, Jiqing; Thiruvaipati, Anusha; Schmidt, Charles R; Eells, Rebecca; Moore, William J; Olejniczak, Edward T; Phan, Jason; Fesik, Stephen W

Drugging Challenging Cancer Targets Using Fragment-Based Methods

利用基于片段的方法靶向治疗具有挑战性的癌症靶点

Fesik, Stephen W

The BCL-2 protein family: from discovery to drug development

BCL-2蛋白家族:从发现到药物研发

Croce, Carlo M; Vaux, David; Strasser, Andreas; Opferman, Joseph T; Czabotar, Peter E; Fesik, Stephen W

Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)

发现与SOS2结合的小分子

Krzysztof M Zak, Alex G Waterson, Leonhard Geist, Nina Braun, Katja Hauer, Klaus Rumpel, Juergen Ramharter, Heinz Stadtmueller, Bernhard Wolkerstorfer, David Schoenbauer, Jianwen Cui, Jason Phan, Jason R Abbott, Dhruba Sarkar, Timothy R Hodges, Allison Arnold, John L Sensintaffar, Stephen W Fesik, D

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model

发现具有强效细胞活性和在小鼠实体瘤异种移植模型中体内活性的巨环髓系细胞白血病1 (Mcl-1) 抑制剂

Tarr, James C; Jeon, Kyuok; Veerasamy, Nagarathanam; Aichinger, Martin; Salovich, James M; Zhao, Bin; Sensintaffar, John L; Arnhof, Heribert; Wunberg, Tobias; Sgubin, Danielle; Arnold, Allison; Vekariya, Rakesh H; Christov, Plamen P; Kim, Kwangho; Fuchs, Julian Emanuel; Karier, Pol; Betzemeier, Bodo; Van Meveren, Mayme; Miriyala, Nagaraju; Olejniczak, Edward T; Engelhardt, Harald; Lee, Taekyu; McConnell, Darryl; Fesik, Stephen W

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

发现 BI-2493,一种泛 KRAS 抑制剂,显示出体内疗效

Bröker Joachim, Waterson Alex G, Hodges Timothy R, Abbott Jason R, Arnold Allison, Böttcher Jark, Braun Nina, Cui Jianwen, Fuchs Julian E, Gerstberger Thomas, Gogg Sebastian, Hanner Sabine, Herdeis Lorenz, Howell Lucas W, Mantoulidis Andreas, Mayer Moriz, Phan Jason, Rocchetti Francesca, Sankar Kyra, Sarkar Dhruba, Schaaf Otmar, Sensintaffar John L, Sun Qi, Wunberg Tobias, Fesik Stephen W

Nuclear Magnetic Resonance-based fragment screen of the E3 ligase Fem-1 homolog B

基于核磁共振的E3连接酶Fem-1同源物B片段筛选

Katinas, Jade M; Amporndanai, Kangsa; Taylor, Ashley J; Rose, Kristie L; Gareiss, Peter C; Crespo, Roberto A; Phan, Jason; Waterson, Alex G; Fesik, Stephen W

NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex

基于核磁共振的von Hippel-Lindau Elongin C&B复合物片段筛选

Amporndanai, Kangsa; Katinas, Jade M; Chopra, Ashima; Kayode, Olumide; Vadukoot, Anish K; Waterson, Alex G; Fesik, Stephen W