日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Towards next-generation treatment options to combat Plasmodium falciparum malaria

迈向对抗恶性疟原虫疟疾的下一代治疗方案

Okombo, John; Fidock, David A

Regional action needed to halt antimalarial drug resistance in Africa

非洲需要采取区域性行动来遏制抗疟药物耐药性。

Martinez-Vega, Rosario; Ishengoma, Deus S; Gosling, Roly; Rosenthal, Philip J; Dondorp, Arjen; Barnes, Karen I; Nsanzabana, Christian; Djimde, Abdoulaye A; Ochola-Oyier, Lynette I; Tibenderana, James; Chimumbwa, John; Golassa, Lemu; Kapologwe, Ntuli A; Mbacham, Wilfred F; Kamya, Moses R; Fidock, David A; Komatsu, Ryuichi; von Seidlein, Lorenz; Dhorda, Mehul

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity

3-羟基丙脒类化合物(HPAs)的构效关系及其强效的体内抗疟活性

Klein, Saskia; Moritz, Alena; Pessanha de Carvalho, Lais; Knaab, Tanja C; Lungerich, Beate; Meyer, Lukas; Sandström, Jona; Thibaud, Jessica L; de Villiers, Katherine A; Fidock, David A; Wittlin, Sergio; Rottmann, Matthias; Held, Jana; Burckhardt, Bjoern B; Kurz, Thomas

TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance

TKK130 是一种 3-羟基丙脒 (HPA) 类化合物,具有强效的体内抗疟活性和较高的耐药屏障。

Knaab, Tanja C; Moritz, Alena; Pessanha de Carvalho, Lais; Klein, Saskia; Lungerich, Beate; Lohse, Katharina; Kruse, Linn; Mombo-Ngoma, Ghyslain; Orta, Lily; Thibaud, Jessica L; de Villiers, Katherine A; Fidock, David A; Burckhardt, Bjoern B; Held, Jana; Wittlin, Sergio; Kurz, Thomas

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

优化和表征靶向 PfATP4 的 N-乙酰胺吲哚类抗疟药

Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D; Mansouri, Mahta; Calic, Petar P S; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M; Mao, Emma Y; Gancheva, Maria R; Wilson, Danny W; Giannangelo, Carlo; MacRaild, Christopher A; Creek, Darren J; Yeo, Tomas; Sheth, Tanaya; Fidock, David A; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T; Delves, Michael J; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C S; Chowdury, Mrittika; de Koning-Ward, Tania F; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Dans, Madeline G; Sleebs, Brad E

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

对易受ROM8和CSC1突变影响的N-芳基乙酰胺类化合物的抗疟活性进行优化和表征

Nguyen, William; Boulet, Coralie; Dans, Madeline G; Loi, Katie; Jarman, Kate E; Barnes, Claudia B G; Yeo, Tomas; Sheth, Tanaya; Mukherjee, Partha; Chakraborty, Arnish; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Coyle, Rachael; Sevilleno, Nicole; Boonyalai, Nonlawat; Lee, Marcus C S; Rabie, Tayla; Birkholtz, Lyn-Marié; Baud, Delphine; Brand, Stephen; Chowdury, Mrittika; de Koning-Ward, Tania F; Fidock, David A; Gilson, Paul R; Sleebs, Brad E

The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.

恶性疟原虫中持续存在血浆蛋白酶-哌喹悖论

Walsh Breanna, Summers Robert L, Rangel Gabriel W, Hagenah Laura M, Mok Sachel, Llinás Manuel, Fidock David A, Wirth Dyann F, Bopp Selina

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.

喹喔啉类抗血吸虫化合物具有很强的抗疟原虫活性

Rawat Mukul, Padalino Gilda, Adika Edem, Okombo John, Yeo Tomas, Brancale Andrea, Fidock David A, Hoffmann Karl F, Lee Marcus C S

Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost

恶性疟原虫非洲型PfCRT突变异构体虽然罕见,但会导致哌喹耐药性,且会造成严重的适应性损失。

Hagenah, Laura M; Yeo, Tomas; Schindler, Kyra A; Jeon, Jin H; Bloxham, Talia S; Small-Saunders, Jennifer L; Mok, Sachel; Fidock, David A