日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.

恶性疟原虫中持续存在血浆蛋白酶-哌喹悖论

Walsh Breanna, Summers Robert L, Rangel Gabriel W, Hagenah Laura M, Mok Sachel, Llinás Manuel, Fidock David A, Wirth Dyann F, Bopp Selina

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.

喹喔啉类抗血吸虫化合物具有很强的抗疟原虫活性

Rawat Mukul, Padalino Gilda, Adika Edem, Okombo John, Yeo Tomas, Brancale Andrea, Fidock David A, Hoffmann Karl F, Lee Marcus C S

Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins

对青蒿素敏感性不同的非洲和亚洲恶性疟原虫分离株的配子体产生和传播适应性

Proellochs, Nicholas I; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N; Okitwi, Martin; Tumwebaze, Patrick K; Conrad, Melissa D; Clark, Taane G; Fidock, David A; Ménard, Didier; Mok, Sachel; Bousema, Teun

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

Recombinant proteasome provides new avenues for anti-malarial drug development.

重组蛋白酶体为抗疟药物的研发提供了新的途径

Fajtova Pavla, Zhang Hanxiao, Urich Liam, da Silva Elany Barbosa, da Silva Cesar Hoffmann, Almaliti Jehad, Al-Hindy Momen, Boura Evzen, Fidock David A, Kirkman Laura A, Lin Gang, Bogyo Matthew, Gerwick William H, Zhao Jianhua, O'Donoghue Anthony J

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Determinants of piperaquine-resistant malaria in South America

南美洲哌喹耐药疟疾的决定因素

Mok, Sachel; Fidock, David A

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

疟原虫环核苷酸磷酸二酯酶抑制剂可阻断无性血液期发育和蚊子传播

Gomez-Gonzalez Paula-Josefina, Gupta Antima, Drought Laura G, Patel Avnish, Okombo John, van der Watt Mariëtte, Walker-Gray Ryan, Schindler Kyra A, Burkhard Anna Y, Yeo Tomas, Narwal Sunil K, Bloxham Talia S, Flueck Christian, Walker Eloise M, Rey Joshua A, Fairhurst Kate J, Reader Janette, Park Heekuk, Pollard Harry G, Stewart Lindsay B, Brandner-Garrod Luke, Kristan Mojca, Sterk Geert-Jan, van Nuland Youri M, Manko Emilia, van Schalkwyk Donelly A, Zheng Yang, Leurs Rob, Dechering Koen J, Aguiar Anna Caroline C, Guido Rafael V C, Pereira Dhelio B, Tumwebaze Patrick K, Nosbya Samuel L, Rosenthal Philip J, Cooper Roland A, Palmer Mike, Parkinson Tanya, Burrows Jeremy N, Uhlemann Anne-Catrin, Birkholtz Lyn-Marié, Small-Saunders Jennifer L, Duffy James, Fidock David A, Brown Alan, Gardner Mark, Baker David A

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

鉴定出强效且可逆的哌啶甲酰胺类化合物,它们是具有物种选择性的口服活性蛋白酶体抑制剂,可用于治疗疟疾

Lawong Aloysus, Gahalawat Suraksha, Ray Sneha, Ho Nhi, Han Yan, Ward Kurt E, Deng Xiaoyi, Chen Zhe, Kumar Ashwani, Xing Chao, Hosangadi Varun, Fairhurst Kate J, Tashiro Kyuto, Liszczak Glen, Shackleford David M, Katneni Kasiram, Chen Gong, Saunders Jessica, Crighton Elly, Casas Arturo, Robinson Joshua J, Imlay Leah S, Zhang Xiaoyu, Lemoff Andrew, Zhao Zhiyu, Angulo-Barturen Iñigo, Jiménez-Díaz María Belén, Wittlin Sergio, Campbell Simon F, Fidock David A, Laleu Benoît, Charman Susan A, Ready Joseph M, Phillips Margaret A

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann