日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

自噬调节剂 ATG5 通过保护小脑的糖酵解活性来维持小脑功能

Janine Tutas, Marianna Tolve, Ebru Özer-Yildiz, Lotte Ickert, Ines Klein, Quinn Silverman, Filip Liebsch, Frederik Dethloff, Patrick Giavalisco, Heike Endepols, Theodoros Georgomanolis, Bernd Neumaier, Alexander Drzezga, Guenter Schwarz, Bernard Thorens, Graziana Gatto, Christian Frezza, Natalia L K

Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression

抑制 BACE1 会影响其 Aβ 生成和降解活性,并在 BACE1 高水平表达时增加 Aβ42 和 Aβ40 水平

Irem Ulku, Rocher Leung, Fritz Herre, Lina Walther, Adeola Shobo, Paul Saftig, Mark A Hancock, Filip Liebsch, Gerhard Multhaup

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

淀粉样蛋白-β34 的生成机制表明 BACE1 在淀粉样蛋白稳态中起着关键作用

Irem Ulku, Filip Liebsch, S Can Akerman, Jana F Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup

Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants

自动图像分析揭示突触Gephyrin C4剪接变体的不同定位

Filip Liebsch, Fynn R Eggersmann, Yvonne Merkler, Peter Kloppenburg, Günter Schwarz

Biallelic gephyrin variants lead to impaired GABAergic inhibition in a patient with developmental and epileptic encephalopathy

双等位基因 gephyrin 变体导致患有发育性和癫痫性脑病的患者的 GABA 能抑制受损

Arthur Macha, Filip Liebsch, Steffen Fricke, Florian Hetsch, Franziska Neuser, Lena Johannes, Vanessa Kress, Tania Djémié, Jose A Santamaria-Araujo, Catheline Vilain, Alec Aeby, Patrick Van Bogaert, Borislav Dejanovic, Sarah Weckhuysen, Jochen C Meier, Guenter Schwarz

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression

Aβ34 是一种 BACE1 衍生的降解中间体,与淀粉样蛋白清除和阿尔茨海默病进展有关

Filip Liebsch, Luka Kulic, Charlotte Teunissen, Adeola Shobo, Irem Ulku, Vivienne Engelschalt, Mark A Hancock, Wiesje M van der Flier, Peter Kunach, Pedro Rosa-Neto, Philip Scheltens, Judes Poirier, Paul Saftig, Randall J Bateman, John Breitner, Christoph Hock, Gerhard Multhaup

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease

淀粉样蛋白-β 降解中间体 Aβ34 与周细胞有关,并且在阿尔茨海默病患者的脑毛细血管中减少

Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M Nitsch, Gerhard Multhaup, Luka Kulic

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding

APLP1被γ-分泌酶内切,无需先前的胞外域脱落。

Linda Schauenburg, Filip Liebsch, Murat Eravci, Magnus C Mayer, Christoph Weise, Gerhard Multhaup

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

全长细胞β-分泌酶具有三聚体亚基化学计量,其富含硫的跨膜相互作用位点调节细胞溶质铜的区室化

Filip Liebsch, Mark R P Aurousseau, Tobias Bethge, Hugo McGuire, Silvia Scolari, Andreas Herrmann, Rikard Blunck, Derek Bowie, Gerd Multhaup