日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Water Networks as Hydrophobic Recognition Motifs in Proteins

水网络作为蛋白质中的疏水识别基序

Piticchio, Serena G; Martínez-Cartró, Miriam; Scaffidi, Salvatore; Rodríguez-Arévalo, Sergio; Bagán, Andrea; Sánchez-Arfelis, Ainoa; Picaud, Sarah; Krojer, Tobias; Filippakopoulos, Panagis; von Delft, Frank; Escolano, Carmen; Galdeano, Carles; Barril, Xavier

Acetylation reprograms MITF target selectivity and residence time

乙酰化作用会改变MITF靶标选择性和停留时间。

Pakavarin Louphrasitthiphol ,Alessia Loffreda ,Vivian Pogenberg ,Sarah Picaud ,Alexander Schepsky ,Hans Friedrichsen ,Zhiqiang Zeng ,Anahita Lashgari ,Benjamin Thomas ,E Elizabeth Patton ,Matthias Wilmanns ,Panagis Filippakopoulos ,Jean-Philippe Lambert ,Eiríkur Steingrímsson ,Davide Mazza ,Colin R Goding

Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

发现苯并[d]咪唑-6-磺酰胺类化合物作为溴结构域和末端外结构域 (BET) 抑制剂,对第一个溴结构域具有选择性

Cipriano, Alessandra; Milite, Ciro; Feoli, Alessandra; Viviano, Monica; Pepe, Giacomo; Campiglia, Pietro; Sarno, Giuliana; Picaud, Sarah; Imaide, Satomi; Makukhin, Nikolai; Filippakopoulos, Panagis; Ciulli, Alessio; Castellano, Sabrina; Sbardella, Gianluca

BET inhibition disrupts transcription but retains enhancer-promoter contact

BET 抑制会破坏转录但保留增强子-启动子接触

Nicholas T Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O J Davies, Thomas A Milne

BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

甲基转移酶SETD6介导的BRD4甲基化调控选择性转录,从而控制mRNA翻译。

Zlata Vershinin ,Michal Feldman ,Thilo Werner ,Lital Estrella Weil ,Margarita Kublanovsky ,Elina Abaev-Schneiderman ,Menachem Sklarz ,Enid Y N Lam ,Khawla Alasad ,Sarah Picaud ,Barak Rotblat ,Ruth A McAdam ,Vered Chalifa-Caspi ,Marcus Bantscheff ,Trevor Chapman ,Huw D Lewis ,Panagis Filippakopoulos ,Mark A Dawson ,Paola Grandi ,Rab K Prinjha ,Dan Levy

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

胡椒碱通过变构拮抗剂作用调节TRPV2,从而抑制胶质母细胞瘤的进展

Conde, João; Pumroy, Ruth A; Baker, Charlotte; Rodrigues, Tiago; Guerreiro, Ana; Sousa, Bárbara B; Marques, Marta C; de Almeida, Bernardo P; Lee, Sohyon; Leites, Elvira P; Picard, Daniel; Samanta, Amrita; Vaz, Sandra H; Sieglitz, Florian; Langini, Maike; Remke, Marc; Roque, Rafael; Weiss, Tobias; Weller, Michael; Liu, Yuhang; Han, Seungil; Corzana, Francisco; Morais, Vanessa A; Faria, Cláudia C; Carvalho, Tânia; Filippakopoulos, Panagis; Snijder, Berend; Barbosa-Morais, Nuno L; Moiseenkova-Bell, Vera Y; Bernardes, Gonçalo J L

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

解析 BET 溴结构域蛋白 BRD2 和 BRD4 在人类 NK 细胞功能中的作用

Adam P Cribbs, Panagis Filippakopoulos, Martin Philpott, Graham Wells, Henry Penn, Henrik Oerum, Viia Valge-Archer, Marc Feldmann, Udo Oppermann

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

非典型流感嗜血杆菌SapA在闭合构象下的结构揭示了一个狭窄的配体结合腔和一种新型的RNA结合基序。

Lukacik, Petra; Owen, C David; Harris, Gemma; Bolla, Jani Reddy; Picaud, Sarah; Alibay, Irfan; Nettleship, Joanne E; Bird, Louise E; Owens, Raymond J; Biggin, Philip C; Filippakopoulos, Panagis; Robinson, Carol V; Walsh, Martin A

BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

BETs抑制剂可减轻氧化应激并维持杜氏肌营养不良症患者的肌肉完整性

Segatto, Marco; Szokoll, Roberta; Fittipaldi, Raffaella; Bottino, Cinzia; Nevi, Lorenzo; Mamchaoui, Kamel; Filippakopoulos, Panagis; Caretti, Giuseppina

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

通过乙酰化介导的基因组重分布来调节转录因子可用性

Pakavarin Louphrasitthiphol ,Robert Siddaway ,Alessia Loffreda ,Vivian Pogenberg ,Hans Friedrichsen ,Alexander Schepsky ,Zhiqiang Zeng ,Min Lu ,Thomas Strub ,Rasmus Freter ,Richard Lisle ,Eda Suer ,Benjamin Thomas ,Benjamin Schuster-Böckler ,Panagis Filippakopoulos ,Mark Middleton ,Xin Lu ,E Elizabeth Patton ,Irwin Davidson ,Jean-Philippe Lambert ,Matthias Wilmanns ,Eiríkur Steingrímsson ,Davide Mazza ,Colin R Goding