日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing

MK-8527 是一种新型的 HIV-1 逆转录酶易位抑制剂,具有延长给药时间的潜力。

Raheem, Izzat T; Girijavallabhan, Vinay; Fillgrove, Kerry L; Goh, Shih Lin; Bahnck-Teets, Carolyn; Huang, Qian; Li, Fangbiao; Wan, Bang-Lin; O'Donnell, Gregory T; Patteson, Jonathan B; Cilento, Maria E; Bennet, Amrith; Hayes, Robert P; Tummala, Srivanya; McHale, Carolyn; Wiltsie, Judyann; Ellis, Joan; Asante-Appiah, Ernest; Hazuda, Daria J; Hale, Jeffrey; Grobler, Jay A; Xu, Min; Diamond, Tracy L; Lai, Ming-Tain

Effectiveness of islatravir post-exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques

伊斯拉曲韦在恒河猴静脉注射猴免疫缺陷病毒后进行暴露后预防的有效性

Markowitz, Martin; Gettie, Agegnehu; St Bernard, Leslie; Grasperge, Brooke; Vargo, Ryan; Pham, Michelle; Fillgrove, Kerry; Dube, Neal; Diamond, Tracy L; Hazuda, Daria J; Grobler, Jay A

Nonclinical and clinical characterization of the absorption, metabolism, and excretion of islatravir

伊斯拉曲韦的吸收、代谢和排泄的非临床和临床特征

Fillgrove, Kerry L; Matthews, Randolph P; Lu, Bing; Liang, Yuexia; Patel, Munjal; Liu, Wen; Matthews, Catherine Z; Liu, Yang; Stoch, S Aubrey; Sanchez, Rosa I; Iwamoto, Marian

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease

吡唑脲类药物作为低剂量、可穿透血脑屏障的中枢神经系统葡糖基神经酰胺合成酶抑制剂,用于治疗帕金森病

Roecker, Anthony J; Schirripa, Kathy M; Loughran, H Marie; Tong, Ling; Liang, Tao; Fillgrove, Kerry L; Kuo, Yuhsin; Bleasby, Kelly; Collier, Hannah; Altman, Michael D; Ford, Melissa C; Drolet, Robert E; Cosden, Mali; Jinn, Sarah; Hatcher, Nathan G; Yao, Lihang; Kandebo, Monika; Vardigan, Joshua D; Flick, Rosemarie B; Liu, Xiaomei; Minnick, Christina; Price, Laura A; Watt, Marla L; Lemaire, Wei; Burlein, Christine; Adam, Gregory C; Austin, Lauren A; Marcus, Jacob N; Smith, Sean M; Fraley, Mark E

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator

发现MK-8768,一种强效且选择性的mGluR2负变构调节剂

Rudd, Michael T; Manley, Peter J; Hanney, Barbara; Meng, Zhaoyang; Shu, Youheng; de Leon, Pablo; Frie, Jessica L; Han, Yongxin; Wai, Jenny Miu-Chun; Yang, Zhi-Qiang; Perkins, James J; Hurzy, Danielle M; Manikowski, Jesse J; Zhu, Hong; Bungard, Christopher J; Converso, Antonella; Meissner, Robert S; Cosden, Mali L; Hayashi, Ikuo; Ma, Lei; O'Brien, Julie; Uebele, Victor N; Schachter, Joel B; Bhandari, Neetesh; Ward, Gwendolyn J; Fillgrove, Kerry L; Lu, Bing; Liang, Yuexia; Dubost, David C; Puri, Vanita; Eddins, Donnie M; Vardigan, Joshua D; Drolet, Robert E; Kern, Jonathan T; Uslaner, Jason M

A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females

一项 1 期开放标签研究,旨在评估 islatravir (MK-8591) 与口服避孕药左炔诺孕酮/炔雌醇在健康成年女性中的药物相互作用。

Ankrom, Wendy; Jackson Rudd, Deanne; Zhang, Saijuan; Fillgrove, Kerry L; Gravesande, Kezia N; Matthews, Randolph P; Brimhall, Darin; Stoch, S Aubrey; Iwamoto, Marian N

Lack of a Clinically Meaningful Drug Interaction Between the HIV-1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate

HIV-1抗逆转录病毒药物伊斯拉曲韦、多替拉韦和富马酸替诺福韦酯之间缺乏具有临床意义的药物相互作用

Rudd, Deanne Jackson; Zhang, Saijuan; Fillgrove, Kerry L; Fox-Bosetti, Sabrina; Matthews, Randolph P; Friedman, Evan; Armas, Danielle; Stoch, S Aubrey; Iwamoto, Marian

In Vitro Evaluation of the Drug Interaction Potential of Doravirine

多拉韦林药物相互作用潜力的体外评价

Bleasby, Kelly; Fillgrove, Kerry L; Houle, Robert; Lu, Bing; Palamanda, Jairam; Newton, Deborah J; Lin, Meihong; Chan, Grace Hoyee; Sanchez, Rosa I

Extended-Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention

长效MK-8591洗脱植入剂作为艾滋病治疗和预防的候选药物

Stephanie E Barrett ,Ryan S Teller ,Seth P Forster ,Li Li ,Megan A Mackey ,Daniel Skomski ,Zhen Yang ,Kerry L Fillgrove ,Gregory J Doto ,Sandra L Wood ,Jose Lebron ,Jay A Grobler ,Rosa I Sanchez ,Zhen Liu ,Bing Lu ,Tao Niu ,Li Sun ,Marian E Gindy

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

优化新型氮杂苯并咪唑酮 mGluR2 正向变构调节剂的液相色谱和药代动力学特性,并减轻 CYP 毒性药物相互作用

Pero, Joseph E; Rossi, Michael A; Kelly, Michael J 3rd; Lehman, Hannah D G F; Layton, Mark E; Garbaccio, Robert M; O'Brien, Julie A; Magliaro, Brian C; Uslaner, Jason M; Huszar, Sarah L; Fillgrove, Kerry L; Tang, Cuyue; Kuo, Yuhsin; Joyce, Leo A; Sherer, Edward C; Jacobson, Marlene A