日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

在特定时间窗口内,通过基因和药理学手段联合灭活紧密连接的 ADAMTS 蛋白酶,揭示了 versican 蛋白水解和 glypican-6 在心脏发育中的不同作用

Mead Timothy J, Bhutada Sumit, Foulcer Simon J, Peruzzi Niccolò, Nelson Courtney M, Seifert Deborah E, Larkin Jonathan, Tran-Lundmark Karin, Filmus Jorge, Apte Suneel S

The function of glypicans in the mammalian embryo

糖蛋白聚糖在哺乳动物胚胎中的功能

Filmus, Jorge

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling

Glypican-6 和 Glypican-4 通过调节 Hedgehog 和非经典 Wnt 信号刺激胚胎胃生长

Wen Shi, Jorge Filmus

Assembling custom side chains on proteoglycans to interrogate their function in living cells

在蛋白聚糖上组装定制侧链,以研究其在活细胞中的功能

Wang, Wenshuang; Han, Naihan; Xu, Yingying; Zhao, Yunxue; Shi, Liran; Filmus, Jorge; Li, Fuchuan

Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis

鉴定干扰Fli-1 DNA结合以抑制白血病发生的二萜类化合物

Tangjingjun Liu,Lei Xia,Yao Yao,Chen Yan,Yanhua Fan,Babu Gajendran,Jue Yang,You-Jun Li,Juan Chen,Jorge Filmus,David E Spaner,Eldad Zacksenhaus,Xiaojiang Hao,Yaacov Ben-David

Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling

Glypican-6 通过刺激 Hedgehog 信号促进发育中的长骨生长

Mariana Capurro, Tomomi Izumikawa, Philippe Suarez, Wen Shi, Marzena Cydzik, Tomoyuki Kaneiwa, Jean Gariepy, Luisa Bonafe, Jorge Filmus

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

硫酸肝素蛋白聚糖 Glypican-6 在衰竭心脏中上调,并通过 ERK1/2 信号传导调节心肌细胞生长

Arne O Melleby, Mari E Strand, Andreas Romaine, Kate M Herum, Biljana Skrbic, Christen P Dahl, Ivar Sjaastad, Arnt E Fiane, Jorge Filmus, Geir Christensen, Ida G Lunde

Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling

转化酶的加工是磷脂酰肌醇蛋白聚糖-3 诱导的 Hedgehog 信号抑制所必需的

Mariana Capurro, Wen Shi, Tomomi Izumikawa, Hiroshi Kitagawa, Jorge Filmus

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

深入了解蛋白聚糖在乳腺癌生物学和转化医学中的关键作用

Theocharis, Achilleas D; Skandalis, Spyros S; Neill, Thomas; Multhaupt, Hinke A B; Hubo, Mario; Frey, Helena; Gopal, Sandeep; Gomes, Angélica; Afratis, Nikos; Lim, Hooi Ching; Couchman, John R; Filmus, Jorge; Sanderson, Ralph D; Schaefer, Liliana; Iozzo, Renato V; Karamanos, Nikos K

Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3

Gpc1 和 Gpc3 对骨形态发生蛋白信号传导和颅骨成骨的调控

Prem P Dwivedi, Randall H Grose, Jorge Filmus, Charles S T Hii, Cory J Xian, Peter J Anderson, Barry C Powell