日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

出版商更正:GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量。

Gutgesell, Robert M; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D; Knerr, Patrick J; Finan, Brian; DiMarchi, Richard D; Sloop, Kyle W; Samms, Ricardo J; Theis, Fabian J; Tschöp, Matthias H; Müller, Timo D

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.

GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量

Gutgesell Robert M, Khalil Ahmed, Liskiewicz Arkadiusz, Maity-Kumar Gandhari, Novikoff Aaron, Grandl Gerald, Liskiewicz Daniela, Coupland Callum, Karaoglu Ezgi, Akindehin Seun, Castelino Russell, Curion Fabiola, Liu Xue, Garcia-Caceres Cristina, Cebrian-Serrano Alberto, Douros Jonathan D, Knerr Patrick J, Finan Brian, DiMarchi Richard D, Sloop Kyle W, Samms Ricardo J, Theis Fabian J, Tschöp Matthias H, Müller Timo D

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans

每日一次的GLP-1/GIP/胰高血糖素受体三激动剂(NN1706)可降低啮齿动物、猴子和人类的体重。

Finan, Brian; Douros, Jonathan D; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B; Hjøllund, Karina Rahr; Kankam, Martin K; Knerr, Patrick J; Konkar, Anish; Mowery, Stephanie A; Müller, Timo D; Nielsen, John Rømer; Nygård, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.

针对 cAMP 偏向信号传导优化的 GLP-1 类似物可改善肥胖小鼠的体重减轻

Douros Jonathan D, Novikoff Aaron, DuBois Barent, Rohlfs Rebecca, Mokrosinski Jacek, Hogendorf Wouter F J, Augustin Robert, Merkestein Myrte, Egaa Martini Lene Brandt, Linderoth Lars, Gerrard Elliot, Kodra Janos Tibor, Norlin Jenny, Roed Nikolaj Kulahin, Oldenburger Anouk, Mowery Stephanie A, Waldhoer Maria, Perez-Tilve Diego, Finan Brian, Reedtz-Runge Steffen, Müller Timo D, Knerr Patrick J

Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism.

E2 结合的 GLP-1 的雌激素活性是通过细胞内溶酶体酸化和雌酮代谢介导的

Coupland Callum, Sun Na, Khalil Ahmed, Karaoglu Özüm Ezgi, Liskiewicz Arkadiusz, Liskiewicz Daniela, Grandl Gerald, Akindehin Seun, Maity Gandhari, Yang Bin, Finan Brian, Knerr Patrick, Douros Jonathan D, Walch Axel, DiMarchi Richard, Tschöp Matthias H, Müller Timo D, Novikoff Aaron

Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

更正:在心血管代谢疾病的临床前小鼠模型中,GIP受体激动剂可独立于体重减轻改善血脂异常和动脉粥样硬化。

Sachs, Stephan; Götz, Anna; Finan, Brian; Feuchtinger, Annette; DiMarchi, Richard D; Döring, Yvonne; Weber, Christian; Tschöp, Matthias H; Müller, Timo D; Hofmann, Susanna M

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

在心血管代谢疾病的临床前小鼠模型中,GIP受体激动剂可独立于体重减轻改善血脂异常和动脉粥样硬化。

Sachs, Stephan; Götz, Anna; Finan, Brian; Feuchtinger, Annette; DiMarchi, Richard D; Döring, Yvonne; Weber, Christian; Tschöp, Matthias H; Müller, Timo D; Hofmann, Susanna M

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

新一代GLP-1/GIP/胰高血糖素三重激动剂可使肥胖小鼠的体重恢复正常

Knerr, Patrick J; Mowery, Stephanie A; Douros, Jonathan D; Premdjee, Bhavesh; Hjøllund, Karina Rahr; He, Yantao; Kruse Hansen, Ann Maria; Olsen, Anette K; Perez-Tilve, Diego; DiMarchi, Richard D; Finan, Brian