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Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

大西洋鲑鱼（Salmo salar）副产品衍生的蛋白质水解物：抗糖尿病肽的来源

doi:10.1016/j.foodres.2018.01.025

Pádraigín A Harnedy, Vadivel Parthsarathy, Chris M McLaughlin, Martina B O'Keeffe, Philip J Allsopp, Emeir M McSorley, Finbarr P M O'Harte, Richard J FitzGerald

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

长期使用apelin-13酰胺酰化类似物治疗可改善高脂饮食小鼠的糖尿病和血脂谱。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0202350

O'Harte, Finbarr P M; Parthsarathy, Vadivel; Hogg, Christopher; Flatt, Peter R

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

胰高血糖素通过 6-磷酸果糖 2-激酶/果糖 2,6-双磷酸酶-2 与葡萄糖激酶调节蛋白之间的转移，诱导葡萄糖激酶从细胞质易位到肝细胞核

期刊:

影响因子:3.3

doi:10.1016/j.bbamcr.2014.02.006

Kirsty S Cullen, Ziad H Al-Oanzi, Finbarr P M O'Harte, Loranne Agius, Catherine Arden

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes

两种新型Tyr1修饰的抗酶形式的葡萄糖依赖性促胰岛素多肽增强了cAMP生成和胰岛素释放能力，与自发性肥胖糖尿病中显著的降血糖活性相关。

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BJ20020319

Gault, Victor A; Flatt, Peter R; Bailey, Clifford J; Harriott, Patrick; Greer, Brett; Mooney, Mark H; O'harte, Finbarr P M

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

胰岛素缺乏的高脂饮食小鼠中持续的胰高血糖素受体拮抗作用

Proglucagon-Derived Peptides as Therapeutics

胰高血糖素原衍生肽作为治疗药物

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

大西洋鲑鱼（Salmo salar）副产品衍生的蛋白质水解物：抗糖尿病肽的来源

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

长期使用apelin-13酰胺酰化类似物治疗可改善高脂饮食小鼠的糖尿病和血脂谱。

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

胰高血糖素通过 6-磷酸果糖 2-激酶/果糖 2,6-双磷酸酶-2 与葡萄糖激酶调节蛋白之间的转移，诱导葡萄糖激酶从细胞质易位到肝细胞核

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes

两种新型Tyr1修饰的抗酶形式的葡萄糖依赖性促胰岛素多肽增强了cAMP生成和胰岛素释放能力，与自发性肥胖糖尿病中显著的降血糖活性相关。