日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

单细胞分析表明,GSM-15606可减轻空气污染引起的炎症并保护海马神经发生。

Shariq, Mohammad; Pan, Wanqing; Chen, Xiran; Xiang, Wang; Godoy-Lugo, Jose; Peng, Lei; Levi, Jonathan N; Ibreyeva, Albina; Shkirkova, Kristina; Nguyen, Wynnie; Sioutas, Constantinos; Mack, William J; Finch, Caleb E; Thorwald, Max A; Bonaguidi, Michael A

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants

化学性质不同的空气污染物诱导与阿尔茨海默病相关的铁死亡和淀粉样蛋白生成特征

Shkirkova, Kristina; Maria, Naomi S Sta; Anson, Herbert; Aghaei, Yashar; Badami, Mohammad Mahdi; Chakhoyan, Ararat; Godoy-Lugo, Jose A; Chung, Claire; Durra, Salma; Tang-Tan, Angela; Zhao, Lifu; Demetriou, Alexandra; Morales, Manuel; Daggupati, Sindhu; Bent, Isabella; Park, Hyoungjin; Franklin, Caleb; Chen, Selena; Chahine, Giovanni; Dodds-Lewis, Skyye; Morishita, Masako; Jacobs, Russell E; Gout, Jean-François; Mack, Wendy J; Forman, Henry Jay; Benayoun, Bérénice A; Vermulst, Marc; Cohen, Mitchell D; Campen, Matthew; Sioutas, Constantinos; Mack, William J; Finch, Caleb E; Thorwald, Max A

Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

在阿尔茨海默病中,铁相关的脂质过氧化作用在脂筏中增强,而铁死亡抑制因子减少,这一现象已通过小鼠螯合实验得到证实。

Thorwald, Max A; Godoy-Lugo, Jose A; Garcia, Gilberto; Silva, Justine; Kim, Minhoo; Christensen, Amy; Mack, Wendy J; Head, Elizabeth; O'Day, Peggy A; Benayoun, Bérénice A; Morgan, Todd E; Pike, Christian J; Higuchi-Sanabria, Ryo; Forman, Henry Jay; Finch, Caleb E

Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

空气污染会降低小鼠大脑皮层突触体中的突触后 PSD-95 和 NMDA 受体亚基

Godoy-Lugo Jose A, Hicks Daniel, Durra Salma, Massey Emma R, Shkirkova Kristina, Sauri Ariel I, Kerstiens Elizabeth, Chen Selena, Zhao Lifu, Sioutas Constantinos, Mack William J, Finch Caleb E, Thorwald Max A

Ectopic adipose tissue in subsistence populations with minimal coronary disease, large left atria, and very low rates of atrial fibrillation

在以自给自足为生的群体中,异位脂肪组织与冠状动脉疾病极少、左心房较大以及房颤发生率极低有关。

Thompson, Randall C; Trumble, Benjamin C; Cummings, Daniel K; Neunuebel, Angela D; Hooper, Paul L; Wann, Samuel; Allam, Adel H; Neunuebel, Frances; Gans, Benjamin D; King, Samantha I; Seabright, Edmond; Finch, Caleb E; Gatz, Margaret; Buetow, Kenneth; Miyamoto, Michael I; Lombardi, Guido P; Sutherland, M Linda; Sutherland, James D; Ward, Christopher; Lee, Madeleine J; Mahadev, Ashna; Rodriguez, Daniel Eid; Michalik, David E; Rowan, Chris J; Cao, Tianyu; Stieglitz, Jonathan; Quick, Cameron M; Thomas, Gregory S; Narula, Jagat; Dey, Damini; Gurven, Michael; Kaplan, Hillard

Beyond genes and environment: mapping biological stochasticity in aging

超越基因和环境:绘制衰老过程中的生物随机性图谱

Hruby, Adam J; Garcia, Gilberto; Thorwald, Max A; Finch, Caleb E; Johnson, Joshua; Higuchi-Sanabria, Ryo

Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon

在玻利维亚亚马逊地区的采集园艺者中,炎症衰老现象极少发生。

Aronoff, Jacob E; Jenkins, Carrie L; Garcia, Angela R; Koebele, Stephanie V; Ghafoor, Suhail; Woolard, Kate L; Charifson, Mia; Suarez, Ivan M; Eid Rodriguez, Daniel; Beheim, Bret; Cummings, Daniel K; Hooper, Paul L; Kraft, Thomas K; Buetow, Kenneth; Finch, Caleb E; Franck, Maximilien; Cohen, Alan A; Stieglitz, Jonathan; Gurven, Michael; Kaplan, Hillard; Trumble, Benjamin C

Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging

黑猩猩和人类的ApoE同种型在刺激神经突分化方面存在差异,这与结构预测相符,并涉及大脑发育和衰老。

Thorwald, Max A; Cacciottolo, Mafalda; Hou, Xiaogang; Morgan, Todd E; Finch, Caleb E

Physical activity mediates age differences in cognition among Tsimane forager-horticulturalists

体育活动在奇马内族采集园艺者认知能力的年龄差异中起着调节作用

Imms, Phoebe; Chaudhari, Nikhil N; Cummings, Daniel; Eid Rodriguez, Daniel; Barisano, Giuseppe; Hooper, Paul L; Sayre, M Katherine; Seabright, Edmond; Thompson, Randall C; Sutherland, M Linda; Sutherland, James D; Trumble, Benjamin C; Gurven, Michael; Stieglitz, Jonathan; Finch, Caleb E; Kaplan, Hillard S; Mack, Wendy J; Gatz, Margaret; Irimia, Andrei

Lifespan Fluidity and Its Biological Limitations in Socio-Economic Health Differences

社会经济差异中寿命流动性及其生物学限制

Finch, Caleb E; Jylhä, Marja K