日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis

一项针对晚期骨髓纤维化的新型泛赖氨酰氧化酶抑制剂 PXS-5505 的 I/IIa 期试验

Vachhani, Pankit; Tan, Peter; Watson, Anne-Marie; Wu, Shang-Ju; Baker, Ross; Cheung, Stanley; Lee, Sung-Eun; Chen, Chih-Cheng; Chen, Tsai-Yun; Hsiao, Hui-Hua; Lee, Jae Hoon; Masarova, Lucia; Tan, Shuh Ying; Baskar, Jana; Charlton, Brett; Findlay, Alison; Hamprecht, Dieter; Jarolimek, Wolfgang; Leadbetter, Joanna; Miller, John; Morgan, Kristen; Zahoor, Amna; Hobbs, Gabriela

The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.

小分子 LOXL2 抑制剂 SNT-5382 可减少心脏纤维化,并实现强大的临床靶点结合

Perryman Lara, Findlay Alison, Baskar Jana, Charlton Brett, Foot Jonathan, Hamilton Ross, Hamprecht Dieter, Joshi Amar, Stolp Jessica, Turner Craig, Zahoor Amna, Zhou Wenbin, López Begoña, Ravassa Susana, González Arantxa, Jarolimek Wolfgang

Use of FLOSEAL® as a scaffold and its impact on induced neural stem cell phenotype, persistence, and efficacy

使用 FLOSEAL® 作为支架及其对诱导神经干细胞表型、持久性和功效的影响

Hunter N Bomba, Abigail Carey-Ewend, Kevin T Sheets, Alain Valdivia, Morgan Goetz, Ingrid A Findlay, Alison Mercer-Smith, Lauren E Kass, Simon Khagi, Shawn D Hingtgen

An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies

一种基于活性的生物探针能够区分新型小分子抑制剂和LOXL2抗体,并为抗纤维化治疗策略带来新的希望。

Findlay, Alison; Turner, Craig; Schilter, Heidi; Deodhar, Mandar; Zhou, Wenbin; Perryman, Lara; Foot, Jonathan; Zahoor, Amna; Yao, Yimin; Hamilton, Ross; Brock, Mary; Raso, Christina; Stolp, Jessica; Galati, Marie; Hamprecht, Dieter; Charlton, Brett; Jarolimek, Wolfgang

Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice

新型赖氨酰氧化酶抑制剂可减轻小鼠原发性骨髓纤维化的典型特征

Leiva, Orly; Ng, Seng Kah; Matsuura, Shinobu; Chitalia, Vipul; Lucero, Hector; Findlay, Alison; Turner, Craig; Jarolimek, Wolfgang; Ravid, Katya