日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

鞘氨醇通过与输入蛋白和PPP2R1A结合,同时抑制核输入并激活PP2A。

Vaishali Jayashankar # ,Peter Kubiniok # ,Alison N McCracken # ,Rebeca G Gentry ,Kazumi H Eckenstein ,Lorenzo Sernissi ,Vito Vece ,Jean-Baptiste Garsi ,Sarah Y Valles ,Sunhee Jung ,Natalie C Hoffman ,Arielle S Perrochon ,Elizabeth M Selwan ,Brendan T Finicle ,Mary Pitman ,DaWei Lin ,Éric Bonneil ,Ruijuan Xu ,Cungui Mao ,Peter Kaiser ,David A Fruman ,David Mobley ,Cholsoon Jang ,Stephen Hanessian ,Pierre Thibault ,Aimee L Edinger

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

同时抑制内吞循环和溶酶体融合使细胞和组织对寡核苷酸疗法敏感

Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

动态磷酸化蛋白质组学揭示抗癌鞘脂类似物调控的信号通路

Peter Kubiniok ,Brendan T Finicle ,Fanny Piffaretti ,Alison N McCracken ,Michael Perryman ,Stephen Hanessian ,Aimee L Edinger ,Pierre Thibault

Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

靶向蛋白磷酸酶2A的受限鞘脂-吩恶嗪/吩噻嗪杂合构建体的设计、合成及抗癌活性

Garsi, Jean-Baptiste; Vece, Vito; Sernissi, Lorenzo; Auger-Morin, Catherine; Hanessian, Stephen; McCracken, Alison N; Selwan, Elizabeth; Ramirez, Cuauhtemoc; Dahal, Amogha; Romdhane, Nadine Ben; Finicle, Brendan T; Edinger, Aimee L

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

PTEN 缺乏和 AMPK 激活促进前列腺癌细胞的营养物质吸收和合成代谢

Kim, Seong M; Nguyen, Tricia T; Ravi, Archna; Kubiniok, Peter; Finicle, Brendan T; Jayashankar, Vaishali; Malacrida, Leonel; Hou, Jue; Robertson, Jane; Gao, Dong; Chernoff, Jonathan; Digman, Michelle A; Potma, Eric O; Tromberg, Bruce J; Thibault, Pierre; Edinger, Aimee L

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

鞘脂通过使ARF6失活来抑制营养转运蛋白的内体循环。

Brendan T Finicle ,Manuel U Ramirez ,Gang Liu ,Elizabeth M Selwan ,Alison N McCracken ,Jingwen Yu ,Yoosun Joo ,Jannett Nguyen ,Kevin Ou ,Saurabh Ghosh Roy ,Victor D Mendoza ,Dania Virginia Corrales ,Aimee L Edinger

Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper

缺乏PTEN的饥饿性前列腺癌细胞在营养匮乏的情况下,通过啃食尸体来获取营养,从而茁壮成长。

Jayashankar, Vaishali; Finicle, Brendan T; Edinger, Aimee L

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

通过同时破坏平行营养获取途径来靶向癌症代谢

Seong M Kim, Saurabh G Roy, Bin Chen, Tiffany M Nguyen, Ryan J McMonigle, Alison N McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T Finicle, Tricia T Nguyen, Archna Ravi, Manuel U Ramirez, Tim Wiher, Garret G Guenther, Mari Kono, Atsuo T Sasaki, Lois S Weisman, Eric O P

Attacking the supply wagons to starve cancer cells to death

攻击补给车,使癌细胞挨饿致死。

Selwan, Elizabeth M; Finicle, Brendan T; Kim, Seong M; Edinger, Aimee L