日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA

与亨廷顿病进展加速相关的FAN1基因点突变会改变其在DNA上通过PCNA介导的组装。

Aretz, Jonas; Jeyasankar, Gayathri; Salerno-Kochan, Anna; Thomsen, Maren; Thieulin-Pardo, Gabriel; Haque, Tasir; Monteagudo, Edith; Felsenfeld, Dan; Finley, Michael; Vogt, Thomas F; Boudet, Julien; Prasad, Brinda C

Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition.

通过冷冻电镜阐明人类 MutSβ 的多个高分辨率状态,揭示了 ATP/ADP 结合和异源双链 DNA 识别之间的相互作用

Lee Jung-Hoon, Thomsen Maren, Daub Herwin, Thieulin-Pardo Gabriel, Steinbacher Stefan, Sztyler Agnieszka, Dahiya Vinay, Neudegger Tobias, Dominguez Celia, Iyer Ravi R, Wilkinson Hilary A, Monteagudo Edith, Plotnikov Nikolay V, Felsenfeld Dan P, Haque Tasir S, Finley Michael, Boudet Julien, Vogt Thomas F, Prasad Brinda C

Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation

鉴定能够调节先天免疫激活并抑制肠道炎症的高选择性SIK1/2抑制剂

Babbe, Holger; Sundberg, Thomas B; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T; Mak, Puiying A; Mathur, Ashok; Mercado-Marin, Eduardo V; Metkar, Shailesh; Raymond, Donald D; Rives, Marie-Laure; Rizzolio, Michele; Shaffer, Paul L; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P; Wei, Jianmei; Desai, Prerak T; Ong, Luvena L; Koudriakova, Tatiana; Goldberg, Steven D; Hirst, Gavin; Kaushik, Virendar K; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B; Plevy, Scott; Venable, Jennifer D; Xavier, Ramnik J; Towne, Jennifer E

Leucine retention in lysosomes is regulated by starvation

溶酶体中的亮氨酸保留受饥饿调节

Urmi Bandyopadhyay, Pavlina Todorova, Natalya N Pavlova, Yuma Tada, Craig B Thompson, Lydia W S Finley, Michael Overholtzer

Tuberous sclerosis complex exhibits a new renal cystogenic mechanism

结节性硬化症表现出一种新的肾囊肿形成机制

John J Bissler, Fahad Zadjali, Dave Bridges, Aristotelis Astrinidis, Sharon Barone, Ying Yao, JeAnna R Redd, Brian J Siroky, Yanqing Wang, Joel T Finley, Michael E Rusiniak, Heinz Baumann, Kamyar Zahedi, Kenneth W Gross, Manoocher Soleimani

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)

含有磺酰胺基团的新型广谱抗惊厥药:(S)-N-[(6-氯-2,3-二氢苯并[1,4]二恶英-2-基)甲基]磺酰胺 (JNJ-26489112) 的药理学特性

McComsey, David F; Smith-Swintosky, Virginia L; Parker, Michael H; Brenneman, Douglas E; Malatynska, Ewa; White, H Steve; Klein, Brian D; Wilcox, Karen S; Milewski, Michael E; Herb, Mark; Finley, Michael F A; Liu, Yi; Lubin, Mary Lou; Qin, Ning; Reitz, Allen B; Maryanoff, Bruce E