日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome

肽硼酸恶性疟原虫 SUB1 抑制剂比人类蛋白酶体具有更高的选择性

Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

混合烷基/芳基膦酸酯可识别代谢丝氨酸水解酶作为抗疟靶点

John M Bennett ,Sunil K Narwal ,Stephanie Kabeche ,Daniel Abegg ,Vandana Thathy ,Fiona Hackett ,Tomas Yeo ,Veronica L Li ,Ryan Muir ,Franco Faucher ,Scott Lovell ,Michael J Blackman ,Alexander Adibekian ,Ellen Yeh ,David A Fidock ,Matthew Bogyo

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

释放胆碱的甘油磷酸二酯酶,对疟原虫的磷脂酰胆碱生物合成和血液阶段发育至关重要

Abhinay Ramaprasad #, Paul-Christian Burda #, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James Macrae, Lucy Collinson, Tim Wolf Gilberger, Michael J Blackman

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

疟疾出口蛋白酶的自催化激活可用药物治疗,并且需要蛋白质辅因子

Michele S Y Tan, Konstantinos Koussis, Chrislaine Withers-Martinez, Steven A Howell, James A Thomas, Fiona Hackett, Ellen Knuepfer, Min Shen, Matthew D Hall, Ambrosius P Snijders, Michael J Blackman

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

肽硼酸是疟原虫出口丝氨酸蛋白酶 SUB1 的强效细胞通透性抑制剂

Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Christine R Collins, Abigail J Perrin, Konstantinos Koussis, Claudine Bisson, Michael J Blackman, Aigars Jirgensons

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

疟原虫脱落酶 SUB2 控制入侵时宿主红细胞膜密封

Christine R Collins #, Fiona Hackett #, Steven A Howell, Ambrosius P Snijders, Matthew Rg Russell, Lucy M Collinson, Michael J Blackman

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

蛋白酶级联调节人类疟原虫恶性疟原虫从宿主红细胞中释放

James A Thomas, Michele S Y Tan, Claudine Bisson, Aaron Borg, Trishant R Umrekar, Fiona Hackett, Victoria L Hale, Gema Vizcay-Barrena, Roland A Fleck, Ambrosius P Snijders, Helen R Saibil, Michael J Blackman

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes

恶性疟原虫感染红细胞中的细胞粘附旋钮下方有一个螺旋支架

Jean M Watermeyer, Victoria L Hale, Fiona Hackett, Daniel K Clare, Erin E Cutts, Ioannis Vakonakis, Roland A Fleck, Michael J Blackman, Helen R Saibil

Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage Egress

环核苷酸(cAMP 和 cGMP)测定和捕获 ELISA 用于定量分析恶性疟原虫血液阶段流出

Fiona Hackett, Christine R Collins, Malcolm Strath, Michael J Blackman

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

膜内蛋白水解介导疟原虫入侵红细胞期间关键粘附素的脱落

Rebecca A O'Donnell, Fiona Hackett, Steven A Howell, Moritz Treeck, Nicole Struck, Zita Krnajski, Chrislaine Withers-Martinez, Tim W Gilberger, Michael J Blackman