日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M

1-苄基吲哚-3-甲醇是一种高效的新型小分子抑制剂,可抑制黑色素瘤细胞中的Wnt/β-catenin信号通路,从而协同抑制细胞增殖并破坏小眼畸形相关转录因子M亚型的表达。

Kundu, Aishwarya; Khouri, Michelle G; Aryana, Sheila; Firestone, Gary L

The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation

吲哚-3-甲醇在人黑色素瘤细胞中的抗增殖反应是由其与NEDD4-1的相互作用以及对野生型PTEN降解的干扰所触发的。

Aronchik, Ida; Kundu, Aishwarya; Quirit, Jeanne G; Firestone, Gary L

The serum- and glucocorticoid-induced protein kinase-1 (Sgk-1) mitochondria connection: identification of the IF-1 inhibitor of the F(1)F(0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1

血清和糖皮质激素诱导的蛋白激酶-1 (Sgk-1) 与线粒体的关系:鉴定出 F(1)F(0)-ATPase 的 IF-1 抑制剂为线粒体特异性结合靶点以及内源性 Sgk-1 的应激诱导线粒体定位

O'Keeffe, Bridget A; Cilia, Salvatore; Maiyar, Anita C; Vaysberg, Maria; Firestone, Gary L

Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

吲哚-3-甲醇可破坏雌激素受体α依赖的胰岛素样生长因子-1受体和胰岛素受体底物-1的表达,并抑制人类乳腺癌细胞的增殖

Marconett Crystal N, Singhal Ankur K, Sundar Shyam N, Firestone Gary L

Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands

小综述:核激素受体及其配体对间隙连接动力学的调控

Firestone, Gary L; Kapadia, Bhumika J

Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells

槟榔碱诱导的紧密连接蛋白ZO-1表达和定位紊乱依赖于人子宫内膜Ishikawa细胞中HER2的表达。

Giri, Sarbani; Poindexter, Kevin M; Sundar, Shyam N; Firestone, Gary L

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

吲哚-3-甲醇通过激活Rho激酶活性抑制MDA-MB-231乳腺癌细胞的运动,并诱导应力纤维和黏着斑的形成。

Brew, Christine T; Aronchik, Ida; Kosco, Karena; McCammon, Jasmine; Bjeldanes, Leonard F; Firestone, Gary L

Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements

选择性雌激素受体调节因子调控元件的细胞类型和雌激素受体亚型特异性调控

Ball, Lonnele J; Levy, Nitzan; Zhao, Xiaoyue; Griffin, Chandi; Tagliaferri, Mary; Cohen, Isaac; Ricke, William A; Speed, Terence P; Firestone, Gary L; Leitman, Dale C

Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells

青蒿素选择性地降低雌激素受体α的功能水平,并消除雌激素诱导的人乳腺癌细胞增殖。

Sundar, Shyam N; Marconett, Crystal N; Doan, Victor B; Willoughby, Jamin A Sr; Firestone, Gary L

The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein

乳腺肿瘤细胞中血清和糖皮质激素调节蛋白激酶 (Sgk) 与 Erk/MAPK 的刺激依赖性共定位涉及与核输入蛋白 importin-α 的相互作用。

Buse, Patricia; Maiyar, Anita C; Failor, Kim L; Tran, Susan; Leong, Meredith L L; Firestone, Gary L