日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AAV-mediated gene transfer of a novel microdystrophin ameliorates pathology and enhances muscle function in a mouse model of DMD.

AAV介导的新型微型肌营养不良蛋白基因转移可改善DMD小鼠模型的病理并增强肌肉功能。

Owusu Lawrence, Kim SunJung, Patel Hiren, Foltz Steven, Chan Gary N Y, Kim Kwi Hye, Kopen Aaron, Yang Lin, Lawlor Michael W, Buss Nicholas, Cunningham Justine J, Liu Ye, Danos Olivier, Fiscella Michele

Homophilic wiring principles underpin neuronal network topology in vitro

同型连接原理是体外神经元网络拓扑结构的基础。

Akarca, Danyal; Dunn, Alexander W E; Hornauer, Philipp J; Ronchi, Silvia; Fiscella, Michele; Wang, Congwei; Terrigno, Marco; Jagasia, Ravi; Vértes, Petra E; Mierau, Susanna B; Paulsen, Ole; Eglen, Stephen J; Hierlemann, Andreas; Astle, Duncan E; Schröter, Manuel

2025 White Paper on Recent Issues in Bioanalysis: Redosing Patients with AAV Gene Therapy; CRS Immunogenicity Risk; Shedding Assays; NHP Studies Immunogenicity; CMC vs Bioanalytical Assays; Artificial Intelligence-Powered Genomic Pipelines for NGS (PART 3A - Recommendations on Gene, Cell, and Vaccine Therapies Immunogenicity & Technologies; Biotherapeutics & Biosimilars Immunogenicity Assessment & Clinical Relevance PART 3B - Regulatory Agencies' Input on Immunogenicity/Technologies of Biothera

2025 年生物分析最新问题白皮书:AAV 基因治疗患者的重复给药;细胞因子释放综合征 (CRS) 免疫原性风险;脱落检测;非人灵长类动物 (NHP) 研究的免疫原性;CMC 与生物分析检测;人工智能驱动的 NGS 基因组流程(第 3A 部分 - 关于基因、细胞和疫苗疗法免疫原性及技术的建议;生物治疗药物和生物类似药的免疫原性评估及临床相关性;第 3B 部分 - 监管机构对 Biothera 免疫原性/技术的意见)

Tounekti, Omar; Shubow, Sophie; Wassmer, Sarah; Van Tuyl, Andrea; Yang, Lin; Gong, Binsheng; Abhari, Mohsen Rajabi; Kalina, Warren; Myler, Heather; DelCarpini, Jason; Escobar, David; Fiscella, Michele; Gorovits, Boris; Gupta, Swati; Irvin, Susan C; Irwin, Chad; Jankowski, Wojciech; Jawa, Vibha; Karauzum, Hatice; Kerridge, Claire; Lu, Yanmei; Mayer, Christian; McGregor, Jessica; Melton, Andrew; Murphy, Rocio; Nanra, Jasdeep; Nowocin, Anna; Partridge, Michael A; Prior, Sandra; Sauna, Zuben; Scott, Bradley; Seitzer, Jessica; Stern, Mark; Sugimoto, Hiroshi; Taylor, Melissa; Wong, Adrian; Xiao, Wenming; Xu, Yuanxin; Yang, Tong-Yuan; Yuill, Daisy; Kubiak, Robert J; Thway, Theingi; Gunn, George; Pelto, Ryan; Sumner, Giane; Baltrukonis, Daniel; Dholakiya, Sanjay L; Dogmanits, Shannon; Garofolo, Fabio; Jadhav, Maria; Kramer, Daniel; Meyer, Erik; Mohapatra, Susovan; Mozaffari, Reza; Peng, Kun; Pine, Samuel; Poetzl, Johann; Rasamoelisolo, Michele; Shao, Weiping; Staack, Roland F; Swanson, Steven; Taqui, Atiya; Vauleon, Stephanie; Wang, Yun; Wen, Yi

2024 White Paper on Recent Issues in Bioanalysis: Evolution of Immunogenicity Assessment beyond ADA/NAb; Regulated Genomic/NGS Assays; Hypersensitivity Reactions; Minimum Noise Reduction; False Positive Range; Modernized Vaccine Approaches; NAb/TAb Correlation (PART 3A - Recommendations on Advanced Strategies for Molecular Assays and Immunogenicity of Gene Therapy, Cell Therapy, Vaccine; Biotherapeutics Immunogenicity Assessment & Clinical Relevance PART 3B - Regulatory Agencies' Input on Immun

2024 年生物分析最新问题白皮书:免疫原性评估超越 ADA/NAb 的演变;受监管的基因组/NGS 检测;超敏反应;最小噪声抑制;假阳性范围;现代化疫苗方法;NAb/TAb 相关性(第 3A 部分 - 关于基因治疗、细胞治疗、疫苗的分子检测和免疫原性的高级策略建议;生物治疗免疫原性评估和临床相关性;第 3B 部分 - 监管机构对免疫原性评估的意见)

Tounekti, Omar; Prior, Sandra; Wassmer, Sarah; Xu, Joshua; Wong, Adrian; Fang, Xiaodong; Sonderegger, Ivo; Smeraglia, John; Huleatt, James; Loo, LiNa; Beaver, Christopher; DelCarpini, Jason; Dessy, Francis; Diebold, Sandra; Fiscella, Michele; Garofolo, Fabio; Grimaldi, Christine; Gupta, Swati; Hou, Victor; Irwin, Chad; Jani, Dewal; Joseph, Julie; Kalina, Warren; Kar, Sumit; Kavita, Uma; Lu, Yanmei; Marshall, Jean-Claude; Mayer, Christian; Mora, Johanna; Nolan, Katrina; Peng, Kun; Riccitelli, Nathan; Scully, Ingrid; Seitzer, Jessica; Stern, Mark; Wadhwa, Meenu; Xu, Yuanxin; Verthelyi, Daniela; Sumner, Giane; Clements-Egan, Adrienne; Chen, Cecil; Gorovits, Boris; Torri, Albert; Baltrukonis, Daniel; Gunn, George; Ishii-Watabe, Akiko; Kramer, Daniel; Kubiak, Robert J; Mullins, Garrett; Pan, Luying; Partridge, Michael A; Poetzl, Johann; Rasamoelisolo, Michele; Sirtori, Federico Riccardi; Richards, Susan; Saad, Ola M; Shao, Weiping; Song, Yuan; Song, Sam; Staack, Roland F; Wu, Bonnie; Manangeeswaran, Mohanraj; Thacker, Seth

2024 White paper on recent issues in bioanalysis: Impact of LDT in US and IVDR in EU; AI/ML for High Parameter Flow Cytometry; The rise of Olink Technology; CDx for AAV Gene Therapies; Integrative Bioanalysis by Multiple Platforms; Super Sensitive ADA/NAb LBA (PART 2A - Recommendations on Advanced Strategies for Biomarkers, IVD/CDx Assays (BAV), Cell Based Assays (CBA), and Ligand-Binding Assays (LBA) PART 2B - Regulatory Agencies' Input on Biomarkers, IVD/CDx, and Biomarker Assay Validation)

2024 年生物分析最新议题白皮书:美国实验室自建检测 (LDT) 和欧盟体外诊断医疗器械法规 (IVDR) 的影响;高参数流式细胞术的 AI/ML;Olink 技术的崛起;腺相关病毒 (AAV) 基因疗法的伴随诊断 (CDx);多平台整合生物分析;超灵敏 ADA/NAb 配体结合分析 (LBA)(第二部分 A - 生物标志物、体外诊断/伴随诊断检测 (BAV)、细胞检测 (CBA) 和配体结合分析 (LBA) 的高级策略建议;第二部分 B - 监管机构对生物标志物、体外诊断/伴随诊断和生物标志物检测验证的意见)

Bivi, Nicoletta; Graham, Danielle; Joglekar, Laura; McGuire, Kristina; Stoop, Jeroen; Zoghbi, Jad; Baker, Brian; Bandukwala, Abbas; Bond, Sarah; Buoninfante, Alessandra; Chen, Jeff; Dysinger, Mark; Engelbergs, Jörg; Fiscella, Michele; Garofolo, Fabio; Hopper, Shirley; Jones, Barry; King, Lindsay; Murphy, Rocio; Palmer, Rachel; Sanderink, Gerard; Seyda, Agnes; Tang, Huaping; Van Tuyl, Andrea; Wagner, Leslie; Walravens, Karl; Wang, Kai; Zander, Hilke; Zhu, Liang; Li, Ming; Lin, Yi-Dong; Natalia, Mahwish; Standifer, Nathan; Eck, Steven; Goihberg, Polina; Grugan, Katharine; Hedrick, Michael Nathan; Hopkins, Greg; Kar, Sumit; Keller, Steve; McGrath, Shannon; O'Gorman, Bill; Stevens, Chad; Stevens, Erin; Terszowski, Grzegorz; Trampont, Paul C; Yao, Shuyu; Joyce, Alison; Kumar, Seema; Owen, Carolina; Pine, Samuel; Yearwood, Graham; Cao, Liching; Clausen, Valerie; Coble, Kelly; Culbert, Andria; Gupta, Shalini; Hughes, Richard; Liu, Susana; Lu, Kun; Martello, Rita; Reese, Kimberly J; Stubenrauch, Kay-Gunnar; Wen, Yi

DeePhys: A machine learning-assisted platform for electrophysiological phenotyping of human neuronal networks

DeePhys:一个利用机器学习辅助的人类神经元网络电生理表型分析平台

Hornauer, Philipp; Prack, Gustavo; Anastasi, Nadia; Ronchi, Silvia; Kim, Taehoon; Donner, Christian; Fiscella, Michele; Borgwardt, Karsten; Taylor, Verdon; Jagasia, Ravi; Roqueiro, Damian; Hierlemann, Andreas; Schröter, Manuel

Evaluation of Cellular Immune Response to Adeno-Associated Virus-Based Gene Therapy

腺相关病毒基因治疗的细胞免疫反应评估

Gorovits, Boris; Azadeh, Mitra; Buchlis, George; Fiscella, Michele; Harrison, Travis; Havert, Mike; Janetzki, Sylvia; Jawa, Vibha; Long, Brian; Mahnke, Yolanda D; McDermott, Andrew; Milton, Mark; Nelson, Robert; Vettermann, Christian; Wu, Bonnie

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2

第26届年度计算神经科学会议(CNS*2017):第二部分

Moldin, Steven O; Rubenstein, John L R; Hyman, Steven E; Rubchinsky, Leonid L; Ahn, Sungwoo; Klijn, Wouter; Cumming, Ben; Yates, Stuart; Karakasis, Vasileios; Peyser, Alexander; Woodman, Marmaduke; Diaz-Pier, Sandra; Deraeve, James; Vassena, Eliana; Alexander, William; Beeman, David; Kudela, Pawel; Boatman-Reich, Dana; Anderson, William S; Luque, Niceto R; Naveros, Francisco; Carrillo, Richard R; Ros, Eduardo; Arleo, Angelo; Huth, Jacob; Ichinose, Koki; Park, Jihoon; Kawai, Yuji; Suzuki, Junichi; Mori, Hiroki; Asada, Minoru; Oprisan, Sorinel A; Dave, Austin I; Babaie, Tahereh; Robinson, Peter; Tabas, Alejandro; Andermann, Martin; Rupp, André; Balaguer-Ballester, Emili; Lindén, Henrik; Christensen, Rasmus K; Nakamura, Mari; Barkat, Tania R; Tosi, Zach; Beggs, John; Lonardoni, Davide; Boi, Fabio; Di Marco, Stefano; Maccione, Alessandro; Berdondini, Luca; Jędrzejewska-Szmek, Joanna; Dorman, Daniel B; Blackwell, Kim T; Bauermeister, Christoph; Keren, Hanna; Braun, Jochen; Dornas, João V; Mavritsaki, Eirini; Aldrovandi, Silvio; Bridger, Emma; Lim, Sukbin; Brunel, Nicolas; Buchin, Anatoly; Kerr, Clifford Charles; Chizhov, Anton; Huberfeld, Gilles; Miles, Richard; Gutkin, Boris; Spencer, Martin J; Meffin, Hamish; Grayden, David B; Burkitt, Anthony N; Davey, Catherine E; Tao, Liangyu; Tiruvadi, Vineet; Ali, Rehman; Mayberg, Helen; Butera, Robert; Gunay, Cengiz; Lamb, Damon; Calabrese, Ronald L; Doloc-Mihu, Anca; López-Madrona, Víctor J; Matias, Fernanda S; Pereda, Ernesto; Mirasso, Claudio R; Canals, Santiago; Geminiani, Alice; Pedrocchi, Alessandra; D’Angelo, Egidio; Casellato, Claudia; Chauhan, Ankur; Soman, Karthik; Srinivasa Chakravarthy, V; Muddapu, Vignayanandam R; Chuang, Chao-Chun; Chen, Nan-yow; Bayati, Mehdi; Melchior, Jan; Wiskott, Laurenz; Azizi, Amir Hossein; Diba, Kamran; Cheng, Sen; Smirnova, Elena Y; Yakimova, Elena G; Chizhov, Anton V; Chen, Nan-Yow; Shih, Chi-Tin; Florescu, Dorian; Coca, Daniel; Courtiol, Julie; Jirsa, Viktor K; Covolan, Roberto J M; Teleńczuk, Bartosz; Kempter, Richard; Curio, Gabriel; Destexhe, Alain; Parker, Jessica; Klishko, Alexander N; Prilutsky, Boris I; Cymbalyuk, Gennady; Franke, Felix; Hierlemann, Andreas; da Silveira, Rava Azeredo; Casali, Stefano; Masoli, Stefano; Rizza, Martina; Rizza, Martina Francesca; Masoli, Stefano; Sun, Yinming; Wong, Willy; Farzan, Faranak; Blumberger, Daniel M; Daskalakis, Zafiris J; Popovych, Svitlana; Viswanathan, Shivakumar; Rosjat, Nils; Grefkes, Christian; Daun, Silvia; Gentiletti, Damiano; Suffczynski, Piotr; Gnatkovski, Vadym; De Curtis, Marco; Lee, Hyeonsu; Paik, Se-Bum; Choi, Woochul; Jang, Jaeson; Park, Youngjin; Song, Jun Ho; Song, Min; Pallarés, Vicente; Gilson, Matthieu; Kühn, Simone; Insabato, Andrea; Deco, Gustavo; Glomb, Katharina; Ponce-Alvarez, Adrián; Ritter, Petra; Gilson, Matthieu; Campo, Adria Tauste; Thiele, Alexander; Deeba, Farah; Robinson, P A; van Albada, Sacha J; Rowley, Andrew; Hopkins, Michael; Schmidt, Maximilian; Stokes, Alan B; Lester, David R; Furber, Steve; Diesmann, Markus; Barri, Alessandro; Wiechert, Martin T; DiGregorio, David A; Dimitrov, Alexander G; Vich, Catalina; Berg, Rune W; Guillamon, Antoni; Ditlevsen, Susanne; Cazé, Romain D; Girard, Benoît; Doncieux, Stéphane; Doyon, Nicolas; Boahen, Frank; Desrosiers, Patrick; Laurence, Edward; Doyon, Nicolas; Dubé, Louis J; Eleonora, Russo; Durstewitz, Daniel; Schmidt, Dominik; Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Metzner, Christoph; Devor, Anna; Djurovic, Srdjan; Dale, Anders M; Andreassen, Ole A; Einevoll, Gaute T; Næss, Solveig; Ness, Torbjørn V; Halnes, Geir; Halgren, Eric; Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas H; Andreassen, Ole A; Sætra, Marte J; Hagen, Espen; Schiffer, Alina; Grzymisch, Axel; Persike, Malte; Ernst, Udo; Harnack, Daniel; Ernst, Udo A; Tomen, Nergis; Zucca, Stefano; Pasquale, Valentina; Pica, Giuseppe; Molano-Mazón, Manuel; Chiappalone, Michela; Panzeri, Stefano; Fellin, Tommaso; Oie, Kelvin S; Boothe, David L; Crone, Joshua C; Yu, Alfred B; Felton, Melvin A Jr; Zulfiqar, Isma; Moerel, Michelle; De Weerd, Peter; Formisano, Elia; Boothe, David L; Crone, Joshua C; Felton, Melvin A Jr; Oie, Kelvin; Franaszczuk, Piotr; Diggelmann, Roland; Fiscella, Michele; Hierlemann, Andreas; Franke, Felix; Guarino, Domenico; Antolík, Jan; Davison, Andrew P; Frègnac, Yves; Etienne, Benjamin Xavier; Frohlich, Flavio; Lefebvre, Jérémie; Marcos, Encarni; Mattia, Maurizio; Genovesio, Aldo; Fedorov, Leonid A; Dijkstra, Tjeerd MH; Sting, Louisa; Hock, Howard; Giese, Martin A; Buhry, Laure; Langlet, Clément; Giovannini, Francesco; Verbist, Christophe; Salvadé, Stefano; Giugliano, Michele; Henderson, James A; Wernecke, Hendrik; Sándor, Bulcsú; Gros, Claudius; Voges, Nicole; Dabrovska, Paulina; Riehle, Alexa; Brochier, Thomas; Grün, Sonja; Gu, Yifan; Gong, Pulin; Dumont, Grégory; Novikov, Nikita A; Gutkin, Boris S; Tewatia, Parul; Eriksson, Olivia; Kramer, Andrei; Santos, Joao; Jauhiainen, Alexandra; Kotaleski, Jeanette H; Belić, Jovana J; Kumar, Arvind; Kotaleski, Jeanette Hellgren; Shimono, Masanori; Hatano, Naomichi; Ahmad, Subutai; Cui, Yuwei; Hawkins, Jeff; Senk, Johanna; Korvasová, Karolína; Tetzlaff, Tom; Helias, Moritz; Kühn, Tobias; Denker, Michael; Mana, PierGianLuca; Grün, Sonja; Dahmen, David; Schuecker, Jannis; Goedeke, Sven; Keup, Christian; Goedeke, Sven; Heuer, Katja; Bakker, Rembrandt; Tiesinga, Paul; Toro, Roberto; Qin, Wei; Hadjinicolaou, Alex; Grayden, David B; Ibbotson, Michael R; Kameneva, Tatiana; Lytton, William W; Mulugeta, Lealem; Drach, Andrew; Myers, Jerry G Jr; Horner, Marc; Vadigepalli, Rajanikanth; Morrison, Tina; Walton, Marlei; Steele, Martin; Anthony Hunt, C; Tam, Nicoladie; Amaducci, Rodrigo; Muñiz, Carlos; Reyes-Sánchez, Manuel; Rodríguez, Francisco B; Varona, Pablo; Cronin, Joseph T; Hennig, Matthias H; Iavarone, Elisabetta; Yi, Jane; Shi, Ying; Zandt, Bas-Jan; Van Geit, Werner; Rössert, Christian; Markram, Henry; Hill, Sean; O’Reilly, Christian; Iavarone, Elisabetta; Shi, Ying; Perin, Rodrigo; Lu, Huanxiang; Zandt, Bas-Jan; Bryson, Alexander; Rössert, Christian; Hadrava, Michal; Hlinka, Jaroslav; Hosaka, Ryosuke; Olenik, Mark; Houghton, Conor; Iannella, Nicolangelo; Launey, Thomas; Kameneva, Tatiana; Kotsakidis, Rebecca; Meffin, Hamish; Soriano, Jaymar; Kubo, Takatomi; Inoue, Takao; Kida, Hiroyuki; Yamakawa, Toshitaka; Suzuki, Michiyasu; Ikeda, Kazushi; Abbasi, Samira; Hudson, Amber E; Heck, Detlef H; Jaeger, Dieter; Lee, Joel; Abbasi, Samira; Janušonis, Skirmantas; Saggio, Maria Luisa; Spiegler, Andreas; Stacey, William C; Bernard, Christophe; Lillo, Davide; Bernard, Christophe; Petkoski, Spase; Spiegler, Andreas; Drakesmith, Mark; Jones, Derek K; Zadeh, Ali Sadegh; Kambhampati, Chandra; Karbowski, Jan; Kaya, Zeynep Gokcen; Lakretz, Yair; Treves, Alessandro; Li, Lily W; Lizier, Joseph; Kerr, Cliff C; Masquelier, Timothée; Kheradpisheh, Saeed Reza; Kim, Hojeong; Kim, Chang Sub; Marakshina, Julia A; Vartanov, Alexander V; Neklyudova, Anastasia A; Kozlovskiy, Stanislav A; Kiselnikov, Andrey A; Taniguchi, Kanako; Kitano, Katsunori; Schmitt, Oliver; Lessmann, Felix; Schwanke, Sebastian; Eipert, Peter; Meinhardt, Jennifer; Beier, Julia; Kadir, Kanar; Karnitzki, Adrian; Sellner, Linda; Klünker, Ann-Christin; Kuch, Lena; Ruß, Frauke; Jenssen, Jörg; Wree, Andreas; Sanz-Leon, Paula; Knock, Stuart A; Chien, Shih-Cheng; Maess, Burkhard; Knösche, Thomas R; Cohen, Charles C; Popovic, Marko A; Klooster, Jan; Kole, Maarten HP; Roberts, Erik A; Kopell, Nancy J; Kepple, Daniel; Giaffar, Hamza; Rinberg, Dima; Koulakov, Alex; Forlim, Caroline Garcia; Klock, Leonie; Bächle, Johanna; Stoll, Laura; Giemsa, Patrick; Fuchs, Marie; Schoofs, Nikola; Montag, Christiane; Gallinat, Jürgen; Lee, Ray X; Stephens, Greg J; Kuhn, Bernd; Tauffer, Luiz; Isope, Philippe; Inoue, Katsuma; Ohmura, Yoshiyuki; Yonekura, Shogo; Kuniyoshi, Yasuo; Jang, Hyun Jae; Kwag, Jeehyun; de Kamps, Marc; Lai, Yi Ming; dos Santos, Filipa; Lam, K P; Andras, Peter; Imperatore, Julia; Helms, Jessica; Tompa, Tamas; Lavin, Antonieta; Inkpen, Felicity H; Ashby, Michael C; Lepora, Nathan F; Shifman, Aaron R; Lewis, John E; Zhang, Zhong; Feng, Yeqian; Tetzlaff, Christian; Kulvicius, Tomas; Li, Yinyun; Pena, Rodrigo F O; Bernardi, Davide; Roque, Antonio C; Lindner, Benjamin; Bernardi, Davide; Vellmer, Sebastian; Saudargiene, Ausra; Maninen, Tiina; Havela, Riikka; Linne, Marja-Leena; Powanwe, Arthur; Longtin, Andre; Naveros, Francisco; Garrido, Jesús A; Graham, Joe W; Dura-Bernal, Salvador; Angulo, Sergio L; Neymotin, Samuel A; Antic, Srdjan D

Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity

先天性眼球震颤基因FRMD7是建立方向选择性神经回路不对称性所必需的

Yonehara, Keisuke; Fiscella, Michele; Drinnenberg, Antonia; Esposti, Federico; Trenholm, Stuart; Krol, Jacek; Franke, Felix; Scherf, Brigitte Gross; Kusnyerik, Akos; Müller, Jan; Szabo, Arnold; Jüttner, Josephine; Cordoba, Francisco; Reddy, Ashrithpal Police; Németh, János; Nagy, Zoltán Zsolt; Munier, Francis; Hierlemann, Andreas; Roska, Botond

Structures of Neural Correlation and How They Favor Coding.

神经关联的结构及其对编码的影响

Franke Felix, Fiscella Michele, Sevelev Maksim, Roska Botond, Hierlemann Andreas, da Silveira Rava Azeredo