日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening

利用化合物筛选发现人 Caf1/CNOT7 poly(A) 选择性核酸酶的类药抑制剂

Kaur, Ishwinder; Hashmi, Lubna; Fischer, Peter M; Winkler, Gerlof Sebastiaan

Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease

发现取代的 5-(2-羟基苯甲酰基)-2-吡啶酮类似物作为人 Caf1/CNOT7 核糖核酸酶抑制剂

Kaur, Ishwinder; Jadhav, Gopal P; Fischer, Peter M; Winkler, Gerlof Sebastiaan

Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.

口服替普拉那韦与长链甘油三酯可使药物适度靶向肠道淋巴,但不能有效递送至肠系膜淋巴结中的 HIV-1 储存库

Chu Yenju, Qin Chaolong, Feng Wanshan, Sheriston Charles, Jane Khor Yu, Medrano-Padial Concepción, Watson Birgit E, Chan Teddy, Ling Binhua, Stocks Michael J, Fischer Peter M, Gershkovich Pavel

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

安托芬和泰洛福林前药作为缺氧靶向抗癌药物的设计、合成及体外生物学评价

Omran, Ziad; Guise, Chris P; Chen, Linwei; Rauch, Cyril; Abdalla, Ashraf N; Abdullah, Omeima; Sindi, Ikhlas A; Fischer, Peter M; Smaill, Jeff B; Patterson, Adam V; Liu, Yuxiu; Wang, Qingmin

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding

1-羟基黄嘌呤衍生物通过Mg(2+)依赖性结合抑制人Caf1核酸酶和含Caf1核酸酶复合物。

Airhihen, Blessing; Pavanello, Lorenzo; Jadhav, Gopal P; Fischer, Peter M; Winkler, Gerlof Sebastiaan

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

ISRIB的结合揭示了核苷酸交换因子eIF2B中的一个调控位点。

Zyryanova, Alisa F; Weis, Félix; Faille, Alexandre; Alard, Akeel Abo; Crespillo-Casado, Ana; Sekine, Yusuke; Harding, Heather P; Allen, Felicity; Parts, Leopold; Fromont, Christophe; Fischer, Peter M; Warren, Alan J; Ron, David

Novel selective β(1)-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

用于治疗合并心血管和呼吸系统疾病的新型选择性β(1)-肾上腺素受体拮抗剂

Baker, Jillian G; Gardiner, Sheila M; Woolard, Jeanette; Fromont, Christophe; Jadhav, Gopal P; Mistry, Shailesh N; Thompson, Kevin S J; Kellam, Barrie; Hill, Stephen J; Fischer, Peter M

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

口服含脂质的大麻会导致肠道淋巴系统中大麻素水平升高,并产生显著的免疫调节作用。

Zgair, Atheer; Lee, Jong Bong; Wong, Jonathan C M; Taha, Dhiaa A; Aram, Jehan; Di Virgilio, Daisy; McArthur, Joshua W; Cheng, Yu-Kit; Hennig, Ivo M; Barrett, David A; Fischer, Peter M; Constantinescu, Cris S; Gershkovich, Pavel

Effects of thromboprophylaxis on mesenchymal stromal cells during osteogenic differentiation: an in-vitro study comparing enoxaparin with rivaroxaban

血栓预防对成骨分化过程中间充质基质细胞的影响:一项比较依诺肝素和利伐沙班的体外研究

Hakan Pilge, Julia Fröbel, Silvia J Mrotzek, Johannes C Fischer, Peter M Prodinger, Christoph Zilkens, Bernd Bittersohl, Rüdiger Krauspe

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1

嘌呤-2,6-二酮衍生物作为人多聚腺苷酸选择性核糖核酸酶Caf1抑制剂的发现、合成和生化分析

Jadhav, Gopal P; Kaur, Ishwinder; Maryati, Maryati; Airhihen, Blessing; Fischer, Peter M; Winkler, G Sebastiaan