Flak Jonathan N相关文献与解析，生知库 | 链接生命科学的每一步

GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice.

GCGR激动剂需要下丘脑内侧基底核的GABA能信号传导才能促进肥胖小鼠的体重减轻。

doi:10.1016/j.molmet.2026.102328

Elmendorf Andrew J, Furber Ellen ConceiÃ§Ã£o, Lorentz Betty, Mahler Connor A, Droz Brian A, Cosgrove Richard, Poret Jonquil Marie, Knerr Patrick J, Samms Ricardo J, Flak Jonathan N

High fat diet remodels the gene regulatory networks in the preoptic area

高脂肪饮食会重塑视前区的基因调控网络

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-37692-8

Lazaro, Olivia; Beimfohr, Caleb; App, Britany; Basu, Rashmita; Johnson, Travis S; Flak, Jonathan N

信号转导

发表日期：2026

文献求助收藏

Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes

肥胖和糖尿病中下丘脑腹内侧神经元的功能分离群体：由“阻止糖尿病之路”项目资助的研究报告

期刊:Diabetes

影响因子:7.5

doi:10.2337/dbi24-0011

Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability.

通过下丘脑调节糖异生底物的可用性来控制生理葡萄糖稳态

期刊:Molecular Metabolism

影响因子:6.6

doi:10.1016/j.molmet.2025.102216

Su Jiaao, Hashsham Abdullah, Kodur Nandan, Burton Carla, Mancuso Amanda, Singer Anjan, Wloszek Jennifer, Tomlinson Abigail J, Yacawych Warren T, Flak Jonathan N, Lewis Kenneth T, Oles Lily R, Mori Hiroyuki, Bozadjieva-Kramer Nadejda, Turcu Adina F, MacDougald Ormond A, Myers Martin G, Affinati Alison H

The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP

痛苦与疗效：GLP-1诱导不良事件的核心机制及其通过GIP缓解的作用

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2025.1530985

Douros, Jonathan D; Flak, Jonathan N; Knerr, Patrick J

Hypothalamic neural circuits regulating energy expenditure

下丘脑神经回路调节能量消耗

期刊:

影响因子:

doi:10.1016/bs.vh.2024.07.004

Basu, Rashmita; Flak, Jonathan N

In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus

在未控制的糖尿病中，高血糖素血症和酮症是由于臂旁核中瘦素作用不足所致。

期刊:Endocrinology

影响因子:3.3

doi:10.1210/en.2017-03199

Meek, Thomas H; Matsen, Miles E; Faber, Chelsea L; Samstag, Colby L; Damian, Vincent; Nguyen, Hong T; Scarlett, Jarrad M; Flak, Jonathan N; Myers, Martin G Jr; Morton, Gregory J

A role for leptin-regulated neurocircuitry in subordination stress

瘦素调节的神经回路在从属压力中的作用

期刊:Physiology & Behavior

影响因子:2.5

doi:10.1016/j.physbeh.2016.11.019

Flak, Jonathan N

发表日期：2017

文献求助收藏

Improving incretin-mediated body weight loss via energy expenditure

通过能量消耗改善肠促胰岛素介导的体重减轻

IUPHAR review: From foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes

IUPHAR综述：化敌为友：重新利用胰高血糖素治疗肥胖症和2型糖尿病

GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice.

GCGR激动剂需要下丘脑内侧基底核的GABA能信号传导才能促进肥胖小鼠的体重减轻。

High fat diet remodels the gene regulatory networks in the preoptic area

高脂肪饮食会重塑视前区的基因调控网络

Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes

肥胖和糖尿病中下丘脑腹内侧神经元的功能分离群体：由“阻止糖尿病之路”项目资助的研究报告

Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability.

通过下丘脑调节糖异生底物的可用性来控制生理葡萄糖稳态

The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP

痛苦与疗效：GLP-1诱导不良事件的核心机制及其通过GIP缓解的作用

Hypothalamic neural circuits regulating energy expenditure

下丘脑神经回路调节能量消耗

In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus

在未控制的糖尿病中，高血糖素血症和酮症是由于臂旁核中瘦素作用不足所致。

A role for leptin-regulated neurocircuitry in subordination stress

瘦素调节的神经回路在从属压力中的作用