日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active

HDAC抑制剂罗米地辛使肝癌细胞易受RTK靶向治疗,并具有免疫活性。

Celia Sequera # ,Margherita Grattarola # ,Floriane Cannet ,Aurélie Dobric ,Paula Michea Veloso ,Melissa Methia ,Sylvie Richelme ,Abdessamad El Kaoutari ,Paraskevi Kousteridou ,Delphine Debayle ,Lukas Kübler ,Sandro Nuciforo ,Yannick Boursier ,Mathieu Dupont ,Stefania Pizzimenti ,Giuseppina Barrera ,Jean-William Dupuy ,Frédéric Saltel ,Markus H Heim ,Sophie Vasseur ,Xavier Adhoute ,Fabienne Guillaumond ,Jean-Paul Borg ,Christian Morel ,Flavio Maina

Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury

揭示胆汁酸诱导损伤过程中成人肝祖细胞、炎症和 EGFR 信号之间的新功能相互作用

Juan García-Sáez, María Figueroa-Fuentes, Carlos González-Corralejo, Cesáreo Roncero, Nerea Lazcanoiturburu, Álvaro Gutiérrez-Uzquiza, Javier Vaquero, Ester González-Sánchez, Kunzangla Bhutia, Silvia Calero-Pérez, Flavio Maina, Javier Traba, Ángela M Valverde, Isabel Fabregat, Blanca Herrera, Aránza

Epithelial disruption drives mesendoderm differentiation in human pluripotent stem cells by enabling TGF-β protein sensing

上皮破坏通过激活 TGF-β 蛋白感应来驱动人类多能干细胞中中内胚层分化

Thomas Legier #, Diane Rattier #, Jack Llewellyn, Thomas Vannier, Benoit Sorre, Flavio Maina, Rosanna Dono

MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities

MYC 和 MET 协同驱动具有不同分子特征和脆弱性的肝细胞癌

Celia Sequera #, Margherita Grattarola #, Agnes Holczbauer, Rosanna Dono, Stefania Pizzimenti, Giuseppina Barrera, Kirk J Wangensteen, Flavio Maina

Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling

小鼠肝细胞中野生型 MET 受体水平增强会减弱胰岛素介导的信号传导

Patricia Rada, Fabienne Lamballe, Elena Carceller-López, Ana B Hitos, Celia Sequera, Flavio Maina, Ángela M Valverde

Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN-4 downregulation

通过 GLYPICAN-4 下调增强人类诱导性多能干细胞向中脑多巴胺能神经元谱系的分化

Serena Corti, Remi Bonjean, Thomas Legier, Diane Rattier, Christophe Melon, Pascal Salin, Erik A Toso, Michael Kyba, Lydia Kerkerian-Le Goff, Flavio Maina, Rosanna Dono

The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

AXL-PYK2-PKCα轴是三阴性乳腺癌干细胞通路的关键节点。

Lohit Khera ,Yaron Vinik ,Flavio Maina ,Sima Lev

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

针对BET的合成致死组合揭示了TNBC对铁死亡的内在易感性

Nandini Verma ,Yaron Vinik ,Ashish Saroha ,Nishanth Ulhas Nair ,Eytan Ruppin ,Gordon Mills ,Thomas Karn ,Vinay Dubey ,Lohit Khera ,Harsha Raj ,Flavio Maina ,Sima Lev

Large-Scale Virtual Screening Against the MET Kinase Domain Identifies a New Putative Inhibitor Type

针对 MET 激酶结构域的大规模虚拟筛选确定了一种新的假定抑制剂类型

Emmanuel Bresso, Alessandro Furlan, Philippe Noel, Vincent Leroux, Flavio Maina, Rosanna Dono, Bernard Maigret

C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation

C3G 在肝癌中上调,促进肿瘤生长和进展以及 HGF/MET 通路激活

Celia Sequera, Paloma Bragado, Sara Manzano, Maria Arechederra, Sylvie Richelme, Alvaro Gutiérrez-Uzquiza, Aránzazu Sánchez, Flavio Maina, Carmen Guerrero, Almudena Porras