日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.

AZ14289671 是一种高选择性且能穿透血脑屏障的不可逆 TKI,靶向 EGFRExon20 插入

Swaih Aisha M, Talbot Sara, Savoca Adriana, Thorpe Hannah, Flemington Vikki, Phillips Benjamin, Colclough Nicola, McCoull William, Radeva Veronika, Hargreaves David, Packer Martin J, Felisberto-Rodrigues Catarina, Thomson Clare, Orme Jonathan P, Deane Carly, Smith Aaron, Johnström Peter, Schou Magnus, McWilliams Lisa, Davey Paul, Enget Marianne, O'Neill Daniel, Cosulich Sabina, Floc'h Nicolas

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

正向遗传筛选发现 Sirtuin1 是神经内分泌前列腺癌的驱动因子。

de Almeida, Francisca Nunes; Vasciaveo, Alessandro; Antao, Ainsley Mike; Zou, Min; Di Bernardo, Matteo; de Brot, Simone; Rodriguez-Calero, Antonio; Chui, Alexander; Wang, Alexander L E; Floc'h, Nicolas; Kim, Jaime Y; Afari, Stephanie N; Mukhammadov, Timur; Arriaga, Juan Martín; Lu, Jinqiu; Shen, Michael M; Rubin, Mark A; Califano, Andrea; Abate-Shen, Cory

The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells

EGFR抑制剂奥希替尼耐药持续细胞的治疗脆弱性概况

Criscione, Steven W; Martin, Matthew J; Oien, Derek B; Gorthi, Aparna; Miragaia, Ricardo J; Zhang, Jingwen; Chen, Huawei; Karl, Daniel L; Mendler, Kerrin; Markovets, Aleksandra; Gagrica, Sladjana; Delpuech, Oona; Dry, Jonathan R; Grondine, Michael; Hattersley, Maureen M; Urosevic, Jelena; Floc'h, Nicolas; Drew, Lisa; Yao, Yi; Smith, Paul D

Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells

药物激活减弱的细胞凋亡通路可清除奥希替尼耐药细胞

Martin, Matthew J; Floc'h, Nicolas; Pfeifer, Matthias; Criscione, Steven; Delpuech, Oona; Gagrica, Sladjana; Yao, Yi; McDermott, Ultan; Smith, Paul D

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response

优化基于人群的患者来源肿瘤异种移植研究设计,以更好地预测临床反应

Floc'h, Nicolas; Guerriero, Maria Luisa; Ramos-Montoya, Antonio; Davies, Barry R; Cairns, Jonathan; Karp, Natasha A

The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer

双重靶向Akt/mTOR信号通路在致命性前列腺癌中的应用前景

Floc'h, Nicolas; Abate-Shen, Cory