日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs

受体工程改造能够增强IL-23R信号的反馈控制和稳健性,并凸显细胞内细胞因子受体信号基序的重要性。

Kashtanjeva, Leorina; Ruhland, Christin; Horstmeier, Franz Christian; Thives-Kurenbach, Felix; Ettich, Julia; Padrini, Giacomo; Streuber, Sophie; Scheller, Jürgen; Dittrich, Anna; Floss, Doreen M

iBody-mediated tuning of synthetic cytokine receptor activation via rational nanobody interface engineering

通过合理的纳米抗体界面工程,利用iBody介导调控合成细胞因子受体的激活。

Kunze, Richard; Navratil, Fabian; Beichert, Joana; Geyer, Felix; Floss, Doreen M; Kolmar, Harald; Scheller, Jürgen; Pudewell, Silke

Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies.

利用拮抗性单域抗体靶向主要的促炎性白细胞介素-6型细胞因子受体gp130

Pudewell Silke, Heuser Julia, Dorogobed Inna, Lipinski Britta, Tran Thi Hong Hue, Metzenmacher Pia, Kunze Richard, Geyer Felix, Zielonka Stefan, Floss Doreen M, Kolmar Harald, Moll Jens M, Scheller Jürgen

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B.

霉菌毒素博维菌素是组织蛋白酶 B 的非竞争性抑制剂

Yang Xiaoli, Cea-Medina Pablo, Gopalswamy Mohanraj, Vaidya Aparna, Schavier Sonja, Oltzen Shixin, Moßner Sofie, Huang Anfei, Qi Jing, Hölken Johanna Maria, Teusch Nicole, Floss Doreen M, Uhrberg Markus, Gohlke Holger, Scheu Stefanie

Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function.

对猿类和人类的 CYP4B1 酶进行功能分析,揭示了催化功能适应的进化热点

Hüsken Saskia, Röder Annika, Ptok Johannes, Meyer Anne E, Georg Mats, Schwarz Yannick, Roos Christian, Mätz-Rensing Kerstin, Hutter Michael C, Floss Doreen M, Rettie Allan E, Girhard Marco, Hanenberg Helmut, Wiek Constanze

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95

合成受体平台用于鉴定死亡受体 Fas/CD95 中的功能丧失型单核苷酸变异体和设计突变体

Minafra, Anna Rita; Rafii, Puyan; Mossner, Sofie; Bazgir, Farhad; Floss, Doreen M; Moll, Jens M; Scheller, Jürgen

IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions

IL-12 和 IL-23——结构同源但免疫功能不同的近亲

Floss, Doreen M; Moll, Jens M; Scheller, Jürgen

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.

白细胞介素-6(而非白细胞介素-6受体)在葡聚糖硫酸钠诱导的结肠炎的恢复中发挥作用

Sommer Jan, Engelowski Erika, Baran Paul, Garbers Christoph, Floss Doreen M, Scheller Jürgen