日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.

DNase TREX1 是膜内蛋白酶 SPP 的底物,与疾病发病机制有关

Tever Onur Kerem, Mentrup Torben, Chinn Ivan Kingyue, Ishikuma Hitoshi, Fluhrer Regina, Schmitz Marc, Wehner Rebekka, Behrendt Rayk, Chinen Javier, Schröder Bernd

The N-terminal PA domains of signal-peptide-peptidase-like 2 (SPPL2) proteases impact on TNFα cleavage.

信号肽肽酶样 2 (SPPL2) 蛋白酶的 N 端 PA 结构域影响 TNFα 的切割

Schlosser Christine, Sharrouf Kinda, Papadopoulou Alkmini A, Haug-Kröper Martina, Singh Suman, Johler Maximilian, Pettinger Jonas, Horn Henrike, Koch Marco, Hoeppner Sabine, Fluhrer Regina

Macrophage polarization is associated with postoperative seroma development in breast cancer in the SerMa pilot cohort.

SerMa 试点队列研究发现,巨噬细胞极化与乳腺癌术后血清肿的发生有关

Schneider Felicitas Magdalena, Pochert Nicole, Schittek Fritzi, Köpke Melitta Beatrice, Wild Carl Mathis, Veh Johanna Marie, Rohrmoser Natalie Renate, Kuhn Christina, Urban Birgit, Kahl Klaus-Henning, Schneider Mariella, Mattmer Angelika, Hinske Ludwig Christian, Fluhrer Regina, Golas Monika M, Untch Michael, Kuehn Thorsten, Banys-Paluchowski Maggie, Jeschke Udo, Traidl-Hoffmann Claudia, Dannecker Christian, Ditsch Nina

Physiological functions of SPP/SPPL intramembrane proteases

SPP/SPPL膜内蛋白酶的生理功能

Mentrup, Torben; Cabrera-Cabrera, Florencia; Fluhrer, Regina; Schröder, Bernd

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

SPPL2a 对 TNFα 的非经典释放取决于其跨膜螺旋的构象柔性

Spitz, Charlotte; Schlosser, Christine; Guschtschin-Schmidt, Nadja; Stelzer, Walter; Menig, Simon; Götz, Alexander; Haug-Kröper, Martina; Scharnagl, Christina; Langosch, Dieter; Muhle-Goll, Claudia; Fluhrer, Regina

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins

信号肽肽酶样蛋白2c会损害囊泡运输并切割SNARE蛋白。

Papadopoulou, Alkmini A; Müller, Stephan A; Mentrup, Torben; Shmueli, Merav D; Niemeyer, Johannes; Haug-Kröper, Martina; von Blume, Julia; Mayerhofer, Artur; Feederle, Regina; Schröder, Bernd; Lichtenthaler, Stefan F; Fluhrer, Regina

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

哺乳动物膜蛋白胞外结构域的蛋白水解脱落——硬件、概念和最新进展

Lichtenthaler, Stefan F; Lemberg, Marius K; Fluhrer, Regina

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

三种膜内切割蛋白酶对神经调节蛋白1 III型的蛋白水解加工

Fleck, Daniel; Voss, Matthias; Brankatschk, Ben; Giudici, Camilla; Hampel, Heike; Schwenk, Benjamin; Edbauer, Dieter; Fukumori, Akio; Steiner, Harald; Kremmer, Elisabeth; Haug-Kröper, Martina; Rossner, Moritz J; Fluhrer, Regina; Willem, Michael; Haass, Christian

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process

γ-分泌酶对β-淀粉样前体蛋白的膜内蛋白水解是一个异常缓慢的过程。

Kamp, Frits; Winkler, Edith; Trambauer, Johannes; Ebke, Amelie; Fluhrer, Regina; Steiner, Harald

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

早老素内切蛋白水解的三个氨基酸间隔表明,γ-分泌酶介导的膜内蛋白水解是一个普遍的逐步裂解过程。

Fukumori, Akio; Fluhrer, Regina; Steiner, Harald; Haass, Christian