日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci

对不同近交系小鼠寿命的分析发现了多个与长寿相关的基因位点

期刊:Genetics
影响因子:5.1
doi:10.1093/genetics/iyaf081
Mullis, Martin N; Wright, Kevin M; Raj, Anil; Gatti, Daniel M; Reifsnyder, Peter C; Flurkey, Kevin; Archer, Jonathan R; Robinson, Laura; Di Francesco, Andrea; Svenson, Karen L; Korstanje, Ron; Harrison, David E; Ruby, J Graham; Churchill, Gary A
发表日期：2025
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

虾青素和美克洛嗪可延长 UM-HET3 雄性小鼠的寿命；在所用剂量和给药方案下，非瑟酮、SG1002（硫化氢供体）、富马酸二甲酯、霉酚酸和 4-苯基丁酸不会显著影响任何性别的寿命

期刊:Geroscience
影响因子:5.3
doi:10.1007/s11357-023-01011-0
David E Harrison #, Randy Strong #, Peter Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull, David G Watumull, Gino Cortopass
发表日期：2024
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Acarbose improves health and lifespan in aging HET3 mice

阿卡波糖可改善衰老 HET3 小鼠的健康和寿命

期刊:Aging Cell
影响因子:8
doi:10.1111/acel.12898
David E Harrison, Randy Strong, Silvestre Alavez, Clinton Michael Astle, John DiGiovanni, Elizabeth Fernandez, Kevin Flurkey, Michael Garratt, Jonathan A L Gelfond, Martin A Javors, Moshe Levi, Gordon J Lithgow, Francesca Macchiarini, James F Nelson, Stacey J Sukoff Rizzo, Thomas J Slaga, Tim Stearn
发育与干细胞
Senescence
发表日期：2019
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Glycine supplementation extends lifespan of male and female mice.

补充甘氨酸可延长雄性和雌性小鼠的寿命

期刊:Aging Cell
影响因子:7.1
doi:10.1111/acel.12953
Miller Richard A, Harrison David E, Astle C Michael, Bogue Molly A, Brind Joel, Fernandez Elizabeth, Flurkey Kevin, Javors Martin, Ladiges Warren, Leeuwenburgh Christiaan, Macchiarini Francesca, Nelson James, Ryazanov Alexey G, Snyder Jessica, Stearns Timothy M, Vaughan Douglas E, Strong Randy
发表日期：2019
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Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr(db) mice

膳食雷帕霉素对成年雌性C57BLKS/J-Lepr(db)小鼠的心脏保护作用

期刊:Annals of the New York Academy of Sciences
影响因子:4.8
doi:10.1111/nyas.13557
Reifsnyder, Peter C; Ryzhov, Sergey; Flurkey, Kevin; Anunciado-Koza, Rea P; Mills, Ian; Harrison, David E; Koza, Robert A
BLK
发表日期：2018
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Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

用弱雌激素激动剂、抗氧化剂、α-葡萄糖苷酶抑制剂或 Nrf2 诱导剂治疗的雄性小鼠寿命更长

期刊:Aging Cell
影响因子:8
doi:10.1111/acel.12496
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming, Martin A Javors, João Pedro de Magalhães, Paul Anthony Martinez, Joe M McCord, Benjamin F Miller, Michael Müller, James F Nelson, Juliet
免疫/内分泌
发表日期：2016
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Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

雷帕霉素治疗可改善2型糖尿病小鼠模型的葡萄糖代谢

期刊:Aging-Us
影响因子:3.9
doi:10.18632/aging.101117
Reifsnyder, Peter C; Flurkey, Kevin; Te, Austen; Harrison, David E
糖尿病
代谢
发表日期：2016
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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

阿卡波糖、17-α-雌二醇和去甲二氢愈创木酸优先延长雄性小鼠的寿命

期刊:Aging Cell
影响因子:8
doi:10.1111/acel.12170
David E Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon, James F Nelson, Scott Pletcher, James W Simpkins, Daniel Smith, J Erby Wilkinson, Richard A Miller
信号转导
Mouse
发表日期：2014
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Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.

通过饮食限制和 N-乙酰-L-半胱氨酸延长遗传异质小鼠的寿命

期刊:Journals of Gerontology Series A-Biological Sciences and Medical Sciences
影响因子:3.8
doi:10.1093/gerona/glq155
Flurkey Kevin, Astle Clinton M, Harrison David E
其它
发表日期：2010
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Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice

神经内分泌抑制葡萄糖生成和矮小鼠抗癌能力

期刊:Experimental Gerontology
影响因子:4.3
doi:10.1016/j.exger.2008.05.014
Alderman, J McKee; Flurkey, Kevin; Brooks, Natasha L; Naik, Sneha B; Gutierrez, Jonathan M; Srinivas, Urmila; Ziara, Kristen B; Jing, Linhong; Boysen, Gunnar; Bronson, Rod; Klebanov, Simon; Chen, Xian; Swenberg, James A; Stridsberg, Mats; Parker, Carol E; Harrison, David E; Combs, Terry P
肿瘤
肿瘤免疫
发表日期：2009
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