KRAS (G12D) -Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients
利用工程化外泌体进行KRAS（G12D）特异性靶向治疗，可重编程免疫微环境，从而提高胰腺癌患者免疫检查点疗法的疗效。
期刊:
影响因子:
doi:10.1101/2025.03.03.25322827
LeBleu, Valerie S; Smaglo, Brandon G; Mahadevan, Krishnan K; Kirtley, Michelle L; McAndrews, Kathleen M; Mendt, Mayela; Yang, Sujuan; Maldonado, Ana S; Sugimoto, Hikaru; Salvatierra, Maria E; Solis Soto, Luisa M; Finch, Rick; Gagea, Mihai; Fluty, Adam C; Ludtke, Steve J; Lee, J Jack; Jain, Abhinav K; Varadhachary, Gauri; Shroff, Rachna T; Maitra, Anirban; Shpall, Elizabeth; Kalluri, Raghu; Pant, Shubham
RAS
胰腺癌
免疫/内分泌
外泌体
Checkpoint
肿瘤
肿瘤免疫
