日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism

HIV-1蛋白酶自身切割的突变扫描为构象动态机制提供了新的视角

期刊:Journal of Virology
影响因子:3.8
doi:10.1128/jvi.02229-25
Nachum, Gily S; Boucher, Jeffrey I; Flynn, Julia M; Quansah, Princess; Nachum, Sivan; Bolon, Daniel N A
HIV
微生物学
发表日期：2026
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Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation.

酵母 Hsp90 中的显性负突变表明存在一种分流决策机制，该机制旨在将底物蛋白降解

期刊:Molecular Biology of the Cell
影响因子:2.7
doi:10.1091/mbc.E24-07-0309
Flynn Julia M, Joyce Margot E, Bolon Daniel N A
免疫/内分泌
Yeast
发表日期：2025
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Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism

HIV-1蛋白酶自身切割的突变扫描为构象动态机制提供了新的视角

期刊:
影响因子:
doi:10.1101/2025.10.07.680924
Nachum, Gily S; Boucher, Jeffrey I; Flynn, Julia M; Quansah, Princess; Nachum, Sivan; Bolon, Daniel N A
HIV
微生物学
发表日期：2025
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Contributions of Hyperactive Mutations in M(pro) from SARS-CoV-2 to Drug Resistance

SARS-CoV-2 M(pro) 蛋白高活性突变对耐药性的贡献

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.3c00560
Flynn, Julia M; Zvornicanin, Sarah N; Tsepal, Tenzin; Shaqra, Ala M; Kurt Yilmaz, Nese; Jia, Weiping; Moquin, Stephanie; Dovala, Dustin; Schiffer, Celia A; Bolon, Daniel N A
SARS-CoV-2
发表日期：2024
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Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation.

酵母 Hsp90 中的显性负突变揭示了针对底物蛋白进行降解的分类决策机制

期刊:
影响因子:
doi:10.1101/2024.01.02.573950
Flynn Julia M, Joyce Margot E, Bolon Daniel N A
免疫/内分泌
Yeast
发表日期：2024
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Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease

对靶向SARS-CoV-2主蛋白酶的药物耐药潜力进行系统分析

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.3c00125
Flynn, Julia M; Huang, Qiu Yu J; Zvornicanin, Sarah N; Schneider-Nachum, Gila; Shaqra, Ala M; Yilmaz, Nese Kurt; Moquin, Stephanie A; Dovala, Dustin; Schiffer, Celia A; Bolon, Daniel N A
SARS-CoV-2
发表日期：2023
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Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

十亿年来Hsp90进化过程中普遍存在的偶然性和根深蒂固性

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1718133115
Starr, Tyler N; Flynn, Julia M; Mishra, Parul; Bolon, Daniel N A; Thornton, Joseph W
发表日期：2018
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Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction

大肠杆菌中调控σE介导的包膜应激反应的蛋白水解级联的设计原则：分级、缓冲和快速信号转导的关键

期刊:Genes & Development
影响因子:7.7
doi:10.1101/gad.1496707
Chaba, Rachna; Grigorova, Irina L; Flynn, Julia M; Baker, Tania A; Gross, Carol A
信号转导
发表日期：2007
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Sculpting the proteome with AAA(+) proteases and disassembly machines

利用 AAA(+) 蛋白酶和解聚机重塑蛋白质组

期刊:Cell
影响因子:42.5
doi:10.1016/j.cell.2004.09.020
Sauer, Robert T; Bolon, Daniel N; Burton, Briana M; Burton, Randall E; Flynn, Julia M; Grant, Robert A; Hersch, Greg L; Joshi, Shilpa A; Kenniston, Jon A; Levchenko, Igor; Neher, Saskia B; Oakes, Elizabeth S C; Siddiqui, Samia M; Wah, David A; Baker, Tania A
发表日期：2004
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Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation

调节底物选择：SspB 接头蛋白将胞外应激反应调节因子递送至 AAA+ 蛋白酶 ClpXP 进行降解。

期刊:Genes & Development
影响因子:7.7
doi:10.1101/gad.1240104
Flynn, Julia M; Levchenko, Igor; Sauer, Robert T; Baker, Tania A
发表日期：2004
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