Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture
通过基于结构的激活剂设计和溶酶体破裂的功能调控实现NLRP3炎症小体的免疫调节
期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.8b00218
Manna, Saikat; Howitz, William J; Oldenhuis, Nathan J; Eldredge, Alexander C; Shen, Jingjing; Nihesh, Fnu Naorem; Lodoen, Melissa B; Guan, Zhibin; Esser-Kahn, Aaron P
炎症
炎症/感染
信号转导
LRP3
NLRP3
炎性小体
免疫/内分泌
