日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure and mechanism of taniborbactam inhibition of the cefepime-hydrolyzing, partial R2-loop deletion Pseudomonas-derived cephalosporinase variant PDC-88

坦尼博巴坦抑制头孢吡肟水解酶、部分R2环缺失的假单胞菌来源头孢菌素酶变体PDC-88的结构和机制

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00078-25
Mack, Andrew R; Kumar, Vijay; Bethel, Christopher R; Taracila, Magdalena A; Miller, Brittany A; Uehara, Tsuyoshi; Six, David A; Papp-Wallace, Krisztina M; van den Akker, Focco; Bonomo, Robert A
发表日期：2025
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Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury

鉴定出一种可预防急性肾损伤的选择性 SCoR2 抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.2c02089
Hua-Lin Zhou, Alfred Hausladen, Puneet Anand, Malligarjunan Rajavel, Colin T Stomberski, Rongli Zhang, Richard T Premont, William J Greenlee, Focco van den Akker, Jonathan S Stamler
代谢
肾损伤
发表日期：2023
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Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds

探索通过不同支架靶向不同位点抑制空肠弯曲菌可溶性溶解性转糖基酶Cj0843c

期刊:Protein Science
影响因子:4.5
doi:10.1002/pro.4683
Vijay Kumar, Jacob Boorman, William J Greenlee, Ximin Zeng, Jun Lin, Focco van den Akker
发表日期：2023
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Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase

Ω环中的天然蛋白质工程：Y221在铜绿假单胞菌来源的头孢菌素酶对头孢他啶和头孢洛扎耐药性中的作用

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00791-23
Mack, Andrew R; Kumar, Vijay; Taracila, Magdalena A; Mojica, Maria F; O'Shea, Margaret; Schinabeck, William; Silver, Galen; Hujer, Andrea M; Papp-Wallace, Krisztina M; Chen, Shuang; Haider, Shozeb; Caselli, Emilia; Prati, Fabio; van den Akker, Focco; Bonomo, Robert A
发表日期：2023
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Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses

硼酸过渡态抑制剂作为 KPC 和 CTX-M β-内酰胺酶的强效灭活剂：生化和结构分析

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/aac.00930-22
Tahani A Alsenani, María Margarita Rodríguez, Barbara Ghiglione, Magdalena A Taracila, Maria F Mojica, Laura J Rojas, Andrea M Hujer, Gabriel Gutkind, Christopher R Bethel, Philip N Rather, Maria Luisa Introvigne, Fabio Prati, Emilia Caselli, Pablo Power, Focco van den Akker, Robert A Bonomo3
发表日期：2023
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Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase

NMR 揭示的不同构象导致 KPC β-内酰胺酶 D179Y 变体对头孢他啶/阿维巴坦产生耐药性，并对美罗培南和亚胺培南产生敏感性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/aac.02124-21
Magdalena A Taracila #, Christopher R Bethel #, Andrea M Hujer #, Krisztina M Papp-Wallace, Melissa D Barnes, Joseph D Rutter, Jamie VanPelt, Ben A Shurina, Focco van den Akker, Cornelius J Clancy, M Hong Nguyen, Shaoji Cheng, Ryan K Shields, Richard C Page, Robert A Bonomo
信号转导
发表日期：2022
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A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp

一种γ-内酰胺类铁载体抗生素，对多重耐药的铜绿假单胞菌、肺炎克雷伯菌和不动杆菌属细菌有效。

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2021.113436
Goldberg, Joel A; Kumar, Vijay; Spencer, Elizabeth J; Hoyer, Denton; Marshall, Steven H; Hujer, Andrea M; Hujer, Kristine M; Bethel, Christopher R; Papp-Wallace, Krisztina M; Perez, Federico; Jacobs, Michael R; van Duin, David; Kreiswirth, Barry N; van den Akker, Focco; Plummer, Mark S; Bonomo, Robert A
肺炎
微生物学
发表日期：2021
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Structural Characterization of Diazabicyclooctane β-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

二氮杂双环辛烷 β-内酰胺“增强剂”与铜绿假单胞菌青霉素结合蛋白 PBP2 和 PBP3 的复合物的结构表征

期刊:mBio
影响因子:5.1
doi:10.1128/mBio.03058-20
Malligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H Marshall, Krisztina M Papp-Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A Bonomo, Focco van den Akker
发表日期：2021
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Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni

空肠弯曲菌 Cj0843c 溶菌转糖基酶的周转化学和结构表征

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.1c00027
Kumar, Vijay; Mathure, Snigdha A; Lee, Mijoon; Boorman, Jacob; Zeng, Ximin; Lin, Jun; Hesek, Dusan; Lastochkin, Elena; Mobashery, Shahriar; van den Akker, Focco
发表日期：2021
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1055. ARGONAUT-IV: Susceptibility of Carbapenem-resistant Klebsiellae to Ceftibuten/VNRX-5236

1055. ARGONAUT-IV：碳青霉烯耐药克雷伯菌对头孢布烯/VNRX-5236的敏感性

期刊:
影响因子:
doi:10.18553/jmcp.2021.21080
Patwardhan, Pallavi; Proudman, David; Allen, Jeffrey; Lucas, Sedge; Nellesen, Dave; Mack, Andrew R; Bethel, Christopher; Marshall, Steven; Patel, Robin; Patel, Robin; van Duin, David; Fowler, Vance G; Rhoads, Daniel D; Jacobs, Michael; van den Akker, Focco; Six, David A; Moeck, Greg; Papp-Wallace, Krisztina M; Bonomo, Robert A
发表日期：2021
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