日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

发现新型泰乐菌素A类似物ABBV-4083,该类似物具有强效的抗沃尔巴克氏体和抗丝虫活性。

von Geldern, Thomas W; Morton, Howard E; Clark, Rick F; Brown, Brian S; Johnston, Kelly L; Ford, Louise; Specht, Sabine; Carr, Robert A; Stolarik, Deanne F; Ma, Junli; Rieser, Matthew J; Struever, Dominique; Frohberger, Stefan J; Koschel, Marianne; Ehrens, Alexandra; Turner, Joseph D; Hübner, Marc P; Hoerauf, Achim; Taylor, Mark J; Ward, Stephen A; Marsh, Kennan; Kempf, Dale J

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis

阿苯达唑和抗生素具有协同作用,可在丝虫病临床前模型中提供短期抗沃尔巴克氏体治愈性治疗。

Turner, Joseph D; Sharma, Raman; Al Jayoussi, Ghaith; Tyrer, Hayley E; Gamble, Joanne; Hayward, Laura; Priestley, Richard S; Murphy, Emma A; Davies, Jill; Waterhouse, David; Cook, Darren A N; Clare, Rachel H; Cassidy, Andrew; Steven, Andrew; Johnston, Kelly L; McCall, John; Ford, Louise; Hemingway, Janet; Ward, Stephen A; Taylor, Mark J

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

短期高剂量利福平治疗可使沃尔巴克氏体耗竭,这可预测淋巴丝虫病和盘尾丝虫病临床前模型的治愈结果。

Aljayyoussi, Ghaith; Tyrer, Hayley E; Ford, Louise; Sjoberg, Hanna; Pionnier, Nicolas; Waterhouse, David; Davies, Jill; Gamble, Joanne; Metuge, Haelly; Cook, Darren A N; Steven, Andrew; Sharma, Raman; Guimaraes, Ana F; Clare, Rachel H; Cassidy, Andrew; Johnston, Kelly L; Myhill, Laura; Hayward, Laura; Wanji, Samuel; Turner, Joseph D; Taylor, Mark J; Ward, Stephen A

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

一项随机、开放标签的试点试验比较了多西环素、米诺环素、多西环素联合阿苯达唑和单用阿苯达唑治疗盘尾丝虫病的疗效

Klarmann-Schulz, Ute; Specht, Sabine; Debrah, Alexander Yaw; Batsa, Linda; Ayisi-Boateng, Nana Kwame; Osei-Mensah, Jubin; Mubarik, Yusif; Konadu, Peter; Ricchiuto, Arcangelo; Fimmers, Rolf; Arriens, Sandra; Dubben, Bettina; Ford, Louise; Taylor, Mark; Hoerauf, Achim

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

米诺环素作为一种重新利用的抗沃尔巴克氏体成虫杀灭剂:在人淋巴丝虫病小鼠感染模型中优于多西环素方案。

Sharma, Raman; Al Jayoussi, Ghaith; Tyrer, Hayley E; Gamble, Joanne; Hayward, Laura; Guimaraes, Ana F; Davies, Jill; Waterhouse, David; Cook, Darren A N; Myhill, Laura J; Clare, Rachel H; Cassidy, Andrew; Steven, Andrew; Johnston, Kelly L; Ford, Louise; Turner, Joseph D; Ward, Stephen A; Taylor, Mark J

Fit for purpose: do we have the right tools to sustain NTD elimination?

是否符合预期用途:我们是否拥有维持消除被忽视的热带病所需的合适工具?

Reimer, Lisa J; Adams, Emily R; Paine, Mark Ji; Ranson, Hilary; Coleman, Marlize; Thomsen, Edward K; MacPherson, Eleanor E; Hollingsworth, T Deirdre; Kelly-Hope, Louise A; Bockarie, Moses J; Ford, Louise; Harrison, Robert A; Stothard, J Russell; Taylor, Mark J; Hamon, Nicholas; Torr, Stephen J

Absence of Wolbachia endobacteria in the human parasitic nematode Dracunculus medinensis and two related Dracunculus species infecting wildlife

在人类寄生线虫麦地那龙线虫(Dracunculus medinensis)和两种感染野生动物的近缘龙线虫物种中,未发现沃尔巴克氏体内生菌。

Foster, Jeremy M; Landmann, Frédéric; Ford, Louise; Johnston, Kelly L; Elsasser, Sarah C; Schulte-Hostedde, Albrecht I; Taylor, Mark J; Slatko, Barton E

Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus

沃尔巴克氏体脂蛋白:马来布鲁氏丝虫和白纹伊蚊中沃尔巴克氏体肽聚糖相关脂蛋白和IV型分泌系统组分VirB6的丰度、定位和血清学研究

Voronin, Denis; Guimarães, Ana F; Molyneux, Gemma R; Johnston, Kelly L; Ford, Louise; Taylor, Mark J

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

将已批准的人类药典药物重新用于治疗盘尾丝虫病和淋巴丝虫病的沃尔巴克氏体内共生菌。

Johnston, Kelly L; Ford, Louise; Umareddy, Indira; Townson, Simon; Specht, Sabine; Pfarr, Kenneth; Hoerauf, Achim; Altmeyer, Ralf; Taylor, Mark J

Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes

脂蛋白生物合成作为抗沃尔巴克氏体治疗丝虫病的靶点

Johnston, Kelly L; Wu, Bo; Guimarães, Ana; Ford, Louise; Slatko, Barton E; Taylor, Mark J