Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
来自阿尔茨海默病患者脑组织的罕见生物活性tau蛋白寡聚体既支持模板化错误折叠,也支持原纤维形成。
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doi:10.1101/2025.09.24.678227
Quittot, Noé; Sivasankaran, Dhanush; Boeken, Dorothea; Chen, Yu; Chun, Joshua E; Wiedmer, Anne; Derosla, Victoria; Martins, Mariana B M S; Brooks, Forest A; Meisl, Georg; Cotton, Matthew; Arumuganainar, Durga G; Connors, Theresa; Melloni, Alexandra; Frosch, Mathew; Oakley, Derek; Makowski, Lee; Wanunu, Meni; Klenerman, David; Hyman, Bradley T