日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Inducible BRCA1 Expression System with In Vivo Applicability Uncovers Activity of the Combination of ATR and PARP Inhibitors to Overcome Therapy Resistance.

一种具有体内适用性的可诱导 BRCA1 表达系统揭示了 ATR 和 PARP 抑制剂联合使用可克服治疗耐药性的活性。

Irving Elsa, Morcavallo Alaide, Vohhodina-Tretjakova Jekaterina, Wijnhoven Paul W G, Beckett Anna L, Jacques Michael P, Evans Rachel S, Moss Jennifer I, Staniszewska Anna D, Forment Josep V

Micronucleus quantification from whole-slide haematology images using AI serves as a translatable pharmacodynamic biomarker for DNA damage response inhibitors.

利用人工智能技术从全玻片血液学图像中定量微核,可作为DNA损伤反应抑制剂的可转化药效学生物标志物。

Yong Killian H R, Robak Weronika S, Mulderrig Lee, Hughes Adina, Bystry Richard, Wantenaar Tanya, Jones Gemma N, Udriste Maria, Robertson Jack, Forment Josep V, O'Connor Lenka Oplustil, Hill Ross J

Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

遗传证据表明,PARP1 捕获是 BRCA 突变癌细胞中 PARP 抑制剂疗效的驱动因素。

Ribeiro Jonathan, Hansen Kjetil, van Beek Lotte, Stubbs Christopher, Frigola Joan, Talbot Sara, Bentouati Sabrina, Hall James, Wijnhoven Paul W G, Armenia Josh, Schimpl Marianne, Forment Josep V, Albertella Mark R, O'Connor Mark J, Illuzzi Giuditta

Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair.

雄激素受体抑制作用将 PARP 抑制剂在前列腺癌模型中的活性扩展到 BRCA 突变和同源重组修复缺陷之外。

Illuzzi Giuditta, Galbiati Alessandro, Staniszewska Anna D, Hanson Robert, Michaloglou Chrysiis, Cooke Sophie L, Uznańska Karolina, Białecka Maja, Solarczyk Kamil, Dev Harveer S, Massie Charlie E, Albertella Mark R, Leo Elisabetta, Forment Josep V, O'Connor Mark J

Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma.

基因组规模的规律成簇间隔短回文重复序列筛选发现核苷酸代谢是弥漫性大B细胞淋巴瘤中可操作的治疗弱点

Davies Nicholas, Francis Tegan, Oldreive Ceri, Azam Maria, Wilson Jordan, Byrd Philip J, Burley Megan, Sharma-Oates Archana, Keane Peter, Alatawi Sael, Higgs Martin R, Rudzki Zbigniew, Ibrahim Maha, Perry Tracey, Agathanggelou Angelo, Hewitt Anne-Marie, Smith Edward, Bonifer Constanze, O'Connor Mark, Forment Josep V, Murray Paul G, Fennell Eanna, Kelly Gemma, Chang Catherine, Stewart Grant S, Stankovic Tatjana, Kwok Marwan, Taylor Alexander Malcolm

Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance

鉴定出对 WEE1 或 ATR 抑制剂有反应、克服 PARP 抑制剂耐药性的乳腺癌和卵巢癌模型中分子定义的亚群。

Serra, Violeta; Wang, Anderson T; Castroviejo-Bermejo, Marta; Polanska, Urszula M; Palafox, Marta; Herencia-Ropero, Andrea; Jones, Gemma N; Lai, Zhongwu; Armenia, Joshua; Michopoulos, Filippos; Llop-Guevara, Alba; Brough, Rachel; Gulati, Aditi; Pettitt, Stephen J; Bulusu, Krishna C; Nikkilä, Jenni; Wilson, Zena; Hughes, Adina; Wijnhoven, Paul W G; Ahmed, Ambar; Bruna, Alejandra; Gris-Oliver, Albert; Guzman, Marta; Rodríguez, Olga; Grueso, Judit; Arribas, Joaquin; Cortés, Javier; Saura, Cristina; Lau, Alan; Critchlow, Susan; Dougherty, Brian; Caldas, Carlos; Mills, Gordon B; Barrett, J Carl; Forment, Josep V; Cadogan, Elaine; Lord, Christopher J; Cruz, Cristina; Balmaña, Judith; O'Connor, Mark J

Preventing and Overcoming Resistance to PARP Inhibitors: A Focus on the Clinical Landscape

预防和克服PARP抑制剂耐药性:聚焦临床现状

Prados-Carvajal, Rosario; Irving, Elsa; Lukashchuk, Natalia; Forment, Josep V

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

XenofilteR:肿瘤异种移植序列数据中小鼠和人类读段的计算解卷积

Kluin, Roelof J C; Kemper, Kristel; Kuilman, Thomas; de Ruiter, Julian R; Iyer, Vivek; Forment, Josep V; Cornelissen-Steijger, Paulien; de Rink, Iris; Ter Brugge, Petra; Song, Ji-Ying; Klarenbeek, Sjoerd; McDermott, Ultan; Jonkers, Jos; Velds, Arno; Adams, David J; Peeper, Daniel S; Krijgsman, Oscar

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

CDK靶向NBS1促进DNA末端切除、复制重启和同源重组

Falck, Jacob; Forment, Josep V; Coates, Julia; Mistrik, Martin; Lukas, Jiri; Bartek, Jiri; Jackson, Stephen P