日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance

结核分枝杆菌MmpS5L5外排泵的结构和功能分析预示着贝达喹啉耐药性的增加。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2516660122
Fountain, Adam J; Böhning, Jan; McLaughlin, Stephen H; Morgan, Tomos E; Edelstein, Paul H; Troll, Mark; Lamers, Meindert H; Bharat, Tanmay A M; Luisi, Ben F; Ramakrishnan, Lalita
发表日期：2025
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Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.

维拉帕米及其代谢物去甲维拉帕米抑制结核分枝杆菌MmpS5L5外排泵，从而增加贝达喹啉的活性

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2426827122
Fountain Adam J, Waller Natalie J E, Cheung Chen-Yi, Jowsey William, Chrisp Michael T, Troll Mark, Edelstein Paul H, Cook Gregory M, McNeil Matthew B, Ramakrishnan Lalita
代谢
发表日期：2025
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Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion

分枝杆菌海藻糖二霉菌酸酯与宿主Mincle蛋白相互作用，重塑血脑屏障连接，从而入侵大脑。

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2025.116661
Hayes, Megan I; Ravishankar, Sumedha; Shanahan, Jonathan K; Fountain, Adam J; Ramakrishnan, Lalita; Madigan, Cressida A
血脑屏障
神经科学
发表日期：2025
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Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance

对结核分枝杆菌MmpS5L5外排泵的结构和功能分析预示着贝达喹啉耐药性增强的途径。

期刊:
影响因子:
doi:10.1101/2025.06.24.661325
Fountain, Adam J; Böhning, Jan; McLaughlin, Stephen H; Morgan, Tomos E; Edelstein, Paul H; Troll, Mark; Lamers, Meindert H; Bharat, Tanmay A M; Luisi, Ben F; Ramakrishnan, Lalita
发表日期：2025
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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region

通过电荷云进行键交换，WASP 可以灵活协调上游信号：WASP 基本区域具有多种监管角色

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA118.003290
Tetley, George J N; Szeto, Aydan; Fountain, Adam J; Mott, Helen R; Owen, Darerca
WASP
信号转导
发表日期：2018
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