日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation

通过机器学习和高通量实验的闭环整合,设计具有完全杀伤选择性的多特异性抗体

Grace, Justin; Colin, Pierre-Yves; Foxler, Dan; Haynes, Winston; Howsham, Catherine; Kassimatis, Leo; Mavrogonatou, Lida; Mighell, Rebecca; McClory, James; Mullin, Michael; Ogola, Tom; Townsend, Alex; Ravi, Sujata; Wossnig, Leo; van Heeke, Gino

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

HIF-LIMD1 负反馈机制减轻缺氧的促肿瘤发生作用

Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting-Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei-Wei Wang, Paulo S Ribeiro, Michael J Ple

LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death

LIMD1受LMP1信号通路诱导并参与其中,能够保护EBV转化细胞免受DNA损伤诱导的细胞死亡。

Wang, Ling; Howell, Mary E A; McPeak, Brooke; Riggs, Katrina; Kohne, Carissa; Yohanon, Jether Uel; Foxler, Daniel E; Sharp, Tyson V; Moorman, Jonathan P; Yao, Zhi Q; Ning, Shunbin

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

Argonaute蛋白在miRNA沉默中的利用取决于LIM结构域蛋白的磷酸化依赖性募集

Bridge, Katherine S; Shah, Kunal M; Li, Yigen; Foxler, Daniel E; Wong, Sybil C K; Miller, Duncan C; Davidson, Kathryn M; Foster, John G; Rose, Ruth; Hodgkinson, Michael R; Ribeiro, Paulo S; Aboobaker, A Aziz; Yashiro, Kenta; Wang, Xiaozhong; Graves, Paul R; Plevin, Michael J; Lagos, Dimitris; Sharp, Tyson V

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1

PU.1 是肿瘤抑制基因 LIMD1 的主要转录激活因子

Daniel E Foxler, Victoria James, Samuel J Shelton, Thomas Q de A Vallim, Peter E Shaw, Tyson V Sharp