Frabutt相关文献与解析，生知库 | 链接生命科学的每一步

A novel class of self-complementary AAV vectors with multiple advantages based on cceAAV lacking mutant ITR

基于缺乏突变 ITR 的 cceAAV 的一类具有多种优势的新型自互补 AAV 载体

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2024.101206

Junping Zhang, Dylan A Frabutt, Matthew Chrzanowski, Ning Li, Lohra M Miller, Jiahe Tian, Patrick L Mulcrone, Anh K Lam, Benjamin E Draper, Martin F Jarrold, Roland W Herzog, Weidong Xiao

信号转导

发表日期：2024

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Cryptic resolution sites in the vector plasmid lead to the heterogeneities in the rAAV vectors

载体质粒中的隐秘解析位点导致 rAAV 载体的异质性

期刊:Journal of Medical Virology

影响因子:6.8

doi:10.1002/jmv.28433

Junping Zhang, Matthew Chrzanowski, Dylan A Frabutt, Anh K Lam, Patrick L Mulcrone, Lei Li, Barbara A Konkle, Carol H Miao, Weidong Xiao

发表日期：2023

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Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism

用N-乙基马来酰亚胺对AAV9衣壳进行化学修饰可改变载体的组织嗜性

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-023-35547-0

Patrick L Mulcrone # ，Anh K Lam # ，Dylan Frabutt ，Junping Zhang ，Matthew Chrzanowski ，Roland W Herzog ，Weidong Xiao

发表日期：2023

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Comprehensive Comparison of AAV Purification Methods: Iodixanol Gradient Centrifugation vs. Immuno-Affinity Chromatography

AAV 纯化方法的全面比较：碘克沙醇梯度离心法与免疫亲和层析法

期刊:

影响因子:

doi:10.1155/2023/2339702

Anh K Lam, Patrick L Mulcrone, Dylan Frabutt, Junping Zhang, Matthew Chrzanowski, Sreevani Arisa, Maite Munoz, Xin Li, Moanaro Biswas, David Markusic, Roland W Herzog, Weidong Xiao

免疫

发表日期：2023

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Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes

rAAV载体中的亚基因组颗粒是由载体基因组的DNA损伤/断裂和非同源末端连接造成的。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2022.08.027

Zhang, Junping; Guo, Ping; Yu, Xiangping; Frabutt, Dylan A; Lam, Anh K; Mulcrone, Patrick L; Chrzanowski, Matthew; Firrman, Jenni; Pouchnik, Derek; Sang, Nianli; Diao, Yong; Herzog, Roland W; Xiao, Weidong

毒理研究

发表日期：2022

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Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS.

利用 LC-MS/MS 对工程化 AAV 衣壳进行快速、高通量的 LC-MS 表征和肽图谱分析。

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2022.09.008

Lam Anh K, Zhang Junping, Frabutt Dylan, Mulcrone Patrick L, Li Lei, Zeng Lifan, Herzog Roland W, Xiao Weidong

多发性硬化症

发表日期：2022

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Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

rAAV的基因组设计导致小鼠肝脏和脾脏的病理变化

期刊:

影响因子:

doi:10.1155/2022/6807904

Mulcrone, Patrick L; Zhang, Junping; Pride, P Melanie; Lam, Anh K; Frabutt, Dylan A; Ball-Kell, Susan M; Xiao, Weidong

发表日期：2022

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HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

HIV-1 Nef 与细胞周期蛋白 K/CDK13 复合物相互作用，拮抗 SERINC5，从而实现最佳病毒感染性。

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2021.109514

Qingqing Chai ,Sunan Li ,Morgan K Collins ,Rongrong Li ,Iqbal Ahmad ,Silas F Johnson ,Dylan A Frabutt ,Zhichang Yang ,Xiaojing Shen ,Liangliang Sun ,Jian Hu ,Judd F Hultquist ,B Matija Peterlin ,Yong-Hui Zheng

Multiplexed Signal Ion Emission Reactive Release Amplification (SIERRA) Assay for the Culture-Free Detection of Gram-Negative and Gram-Positive Bacteria and Antimicrobial Resistance Genes

多重信号离子发射反应释放扩增 (SIERRA) 检测法用于非培养检测革兰氏阴性和革兰氏阳性细菌及抗菌素耐药基因

期刊:Analytical Chemistry

影响因子:6.7

doi:10.1021/acs.analchem.0c00453

Michael Pugia, Tiyash Bose, Marco Tjioe, Dylan Frabutt, Zane Baird, Zehui Cao, Anna Vorsilak, Ian McLuckey, M Regina Barron, Monica Barron, Gerald Denys, Jessica Carpenter, Amitava Das, Karamjeet Kaur, Sashwati Roy, Chandan K Sen, Frédérique Deiss

微生物学

发表日期：2021

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Simultaneous detection of the AAV genomes and their transcripts in situ at the single-cell level

在单细胞水平上同时检测AAV基因组及其转录本

A novel class of self-complementary AAV vectors with multiple advantages based on cceAAV lacking mutant ITR

基于缺乏突变 ITR 的 cceAAV 的一类具有多种优势的新型自互补 AAV 载体

Cryptic resolution sites in the vector plasmid lead to the heterogeneities in the rAAV vectors

载体质粒中的隐秘解析位点导致 rAAV 载体的异质性

Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism

用N-乙基马来酰亚胺对AAV9衣壳进行化学修饰可改变载体的组织嗜性

Comprehensive Comparison of AAV Purification Methods: Iodixanol Gradient Centrifugation vs. Immuno-Affinity Chromatography

AAV 纯化方法的全面比较：碘克沙醇梯度离心法与免疫亲和层析法

Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes

rAAV载体中的亚基因组颗粒是由载体基因组的DNA损伤/断裂和非同源末端连接造成的。

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS.

利用 LC-MS/MS 对工程化 AAV 衣壳进行快速、高通量的 LC-MS 表征和肽图谱分析。

Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

rAAV的基因组设计导致小鼠肝脏和脾脏的病理变化

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

HIV-1 Nef 与细胞周期蛋白 K/CDK13 复合物相互作用，拮抗 SERINC5，从而实现最佳病毒感染性。

Multiplexed Signal Ion Emission Reactive Release Amplification (SIERRA) Assay for the Culture-Free Detection of Gram-Negative and Gram-Positive Bacteria and Antimicrobial Resistance Genes

多重信号离子发射反应释放扩增 (SIERRA) 检测法用于非培养检测革兰氏阴性和革兰氏阳性细菌及抗菌素耐药基因