日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides

氟虫腈和其他吡唑类杀虫剂诱导淀粉样蛋白β42的产生

Cam, Morgane; Durieu, Emilie; Bodin, Marion; Manousopoulou, Antigoni; Koslowski, Svenja; Vasylieva, Natalia; Barnych, Bogdan; Hammock, Bruce D; Bohl, Bettina; Koch, Philipp; Omori, Chiori; Yamamoto, Kazuo; Hata, Saori; Suzuki, Toshiharu; Karg, Frank; Gizzi, Patrick; Erakovic Haber, Vesna; Bencetic Mihaljevic, Vlatka; Tavcar, Branka; Portelius, Erik; Pannee, Josef; Blennow, Kaj; Zetterberg, Henrik; Garbis, Spiros D; Auvray, Pierrick; Gerber, Hermeto; Fraering, Jeremy; Fraering, Patrick C; Meijer, Laurent

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

锌和铜通过不同的方式调节γ-分泌酶对淀粉样前体蛋白的加工以及淀粉样β肽的产生。

Gerber, Hermeto; Wu, Fang; Dimitrov, Mitko; Garcia Osuna, Guillermo M; Fraering, Patrick C

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

ADAM10 介导的神经连接蛋白 3β 胞外结构域脱落会释放出一个可溶性片段,该片段会影响新生神经元的发育。

Borcel, Erika; Palczynska, Magda; Krzisch, Marine; Dimitrov, Mitko; Ulrich, Giorgio; Toni, Nicolas; Fraering, Patrick C

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

利用扩展焦距光学相干显微镜对脑β-淀粉样变性进行无标记成像

Bolmont, Tristan; Bouwens, Arno; Pache, Christophe; Dimitrov, Mitko; Berclaz, Corinne; Villiger, Martin; Wegenast-Braun, Bettina M; Lasser, Theo; Fraering, Patrick C

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

从白屈菜提取物中发现了一类新型的γ-分泌酶调节剂,该调节剂具有独特的药理学和结构特征。

Findeis, Mark A; Schroeder, Frank; McKee, Timothy D; Yager, Debra; Fraering, Patrick C; Creaser, Steffen P; Austin, Wesley F; Clardy, Jon; Wang, Rong; Selkoe, Dennis; Eckman, Christopher B

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.

纯化γ-分泌酶的冷冻电镜结构,分辨率为12 Å

Osenkowski Pamela, Li Hua, Ye Wenjuan, Li Dongyang, Aeschbach Lorene, Fraering Patrick C, Wolfe Michael S, Selkoe Dennis J, Li Huilin

Gene expression profiling in cells with enhanced gamma-secretase activity

γ-分泌酶活性增强细胞的基因表达谱分析

Magold, Alexandra I; Cacquevel, Matthias; Fraering, Patrick C

Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease

γ-分泌酶的结构和功能决定因素,一种与阿尔茨海默病相关的膜内蛋白酶

Fraering, Patrick C

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

纯化的活性γ-分泌酶的电子显微镜结构显示其具有一个水性膜内腔室和两个孔道。

Lazarov, Vlado K; Fraering, Patrick C; Ye, Wenjuan; Wolfe, Michael S; Selkoe, Dennis J; Li, Huilin