日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profiling biological effects of microbiome metabolites via machine learning

利用机器学习分析微生物组代谢物的生物学效应

Chung, Hong A; Fralish, Zachary; Tu, Tiffany; Reker, Daniel

Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus

为老年科学试验选择合适的临床试验终点:迈向共识之路

Kritchevsky, Stephen; Zamora, Ezequiel; Bhasin, Shalender; Cohen, Alan; Chandler, Allison; Covinsky, Kevin; Crane, Heidi; Cummings, Steven; Erlandson, Kristine; Espeland, Mark; Espinoza, Sara; Ferrucci, Luigi; Fleming, Alexander; Forman, Daniel; LaCroix-Fralish, Michael; Gonzales, Mitzi; Justice, Jamie; Kiel, Douglas; Kuchel, George; Mannick, Joan; Menetski, Joseph; Miller, Michael; Musi, Nicolas; Newman, Anne; Newman, John; Owens, Sarah Simpson; Pandey, Ambarish; Reilly, Kandice; Sedrak, Mina; Wagner, John; Whitson, Heather; Williamson, Jeff

Finding the most potent compounds using active learning on molecular pairs

利用分子对的主动学习方法寻找最有效的化合物。

Fralish, Zachary; Reker, Daniel

Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy

人类 LGMD2B 骨骼肌的生物工程模型揭示了细胞内钙超载在肌萎缩蛋白病的收缩和代谢功能障碍中的作用

Alastair Khodabukus, Neel K Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D Fralish, Megan E Kondash, George A Truskey, Timothy R Koves, Nenad Bursac

DeepDelta: predicting ADMET improvements of molecular derivatives with deep learning

DeepDelta:利用深度学习预测分子衍生物的 ADMET 改进

Fralish, Zachary; Chen, Ashley; Skaluba, Paul; Reker, Daniel

Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog

评估健康寿命评估工具:一项关于伴侣犬健康相关生活质量 (HRQL) 和虚弱程度的多中心横断面研究

Chen, Frances L; Ullal, Tarini V; Graves, Jessica L; Ratcliff, Ellen R; Naka, Alexander; McKenzie, Brennen; Carttar, Tennery A; Super, Kaitlyn M; Austriaco, Jessica; Weber, Sunny Y; Vaughn, Julie; LaCroix-Fralish, Michael L

Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain

针对 GFRα3 的单克隆抗体可有效对抗小鼠关节痛模型中诱发的痛觉过敏和异常性疼痛反应,但其中一种抗体 REGN5069 在一项针对骨关节炎疼痛患者的随机安慰剂对照临床试验中对疼痛无效

Selin Somersan-Karakaya, Kenneth C Turner, Luz Cortes-Burgos, Jutta Miller, Michael LaCroix-Fralish, Veronika Logovinsky, Yamini Patel, Richard Torres, Samit Ganguly, Aurora Breazna, Michelle DeVeaux, Rafia Bhore, Min Gao, Frank J Delfino, Ashique Rafique, Jeanette L Fairhurst, Charleen Hunt, Robert

AdRoit is an accurate and robust method to infer complex transcriptome composition

AdRoit 是一种准确且稳健的方法,可用于推断复杂的转录组组成。

Yang, Tao; Alessandri-Haber, Nicole; Fury, Wen; Schaner, Michael; Breese, Robert; LaCroix-Fralish, Michael; Kim, Jinrang; Adler, Christina; Macdonald, Lynn E; Atwal, Gurinder S; Bai, Yu

Neuromuscular Development and Disease: Learning From in vitro and in vivo Models

神经肌肉发育与疾病:从体外和体内模型中汲取经验

Fralish, Zachary; Lotz, Ethan M; Chavez, Taylor; Khodabukus, Alastair; Bursac, Nenad

Foxd4 is essential for establishing neural cell fate and for neuronal differentiation

Foxd4对于确定神经细胞命运和神经元分化至关重要。

Sherman, Jonathan H; Karpinski, Beverly A; Fralish, Matthew S; Cappuzzo, Justin M; Dhindsa, Devinder S; Thal, Arielle G; Moody, Sally A; LaMantia, Anthony S; Maynard, Thomas M