日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

靶向 FAK 和 MEK 的药物组合克服了胶质母细胞瘤的肿瘤异质性

Furqan Muhammad, Elliott Richard J R, Nagle Peter W K, Dawson John C, Masalmeh Roza, Garcia Virginia Alvarez, Munro Alison F, Drake Camilla, Morrison Gillian M, Pollard Steven M, Ebner Daniel, Brunton Valerie G, Frame Margaret C, Carragher Neil O

Targeting FAK in anticancer combination therapies

在抗癌联合疗法中靶向FAK

Dawson, John C; Serrels, Alan; Stupack, Dwayne G; Schlaepfer, David D; Frame, Margaret C

Structural basis of Focal Adhesion Kinase activation on lipid membranes

脂质膜上黏着斑激酶激活的结构基础

Acebrón, Iván; Righetto, Ricardo D; Schoenherr, Christina; de Buhr, Svenja; Redondo, Pilar; Culley, Jayne; Rodríguez, Carlos F; Daday, Csaba; Biyani, Nikhil; Llorca, Oscar; Byron, Adam; Chami, Mohamed; Gräter, Frauke; Boskovic, Jasminka; Frame, Margaret C; Stahlberg, Henning; Lietha, Daniel

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

快速发现并阐明吡唑并嘧啶类化合物的构效关系,该类化合物通过抑制SRC激酶有效抑制乳腺癌细胞生长,且对ABL激酶具有极高的选择性。

Fraser, Craig; Dawson, John C; Dowling, Reece; Houston, Douglas R; Weiss, Jason T; Munro, Alison F; Muir, Morwenna; Harrington, Lea; Webster, Scott P; Frame, Margaret C; Brunton, Valerie G; Patton, E Elizabeth; Carragher, Neil O; Unciti-Broceta, Asier

The ROCKs on which tumour cells thrive

肿瘤细胞赖以生存的岩石

Wilkinson, Simon; Frame, Margaret C

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy

FAK 进入核内以控制抗肿瘤免疫——癌症免疫疗法的新靶点

Serrels, Alan; Frame, Margaret C

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

黏附蛋白网络揭示了细胞-基质接触近端和远端的功能。

Byron, Adam; Frame, Margaret C

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

核FAK调控趋化因子转录、调节性T细胞(Tregs)以及肿瘤细胞逃避免疫反应。

Serrels, Alan; Lund, Tom; Serrels, Bryan; Byron, Adam; McPherson, Rhoanne C; von Kriegsheim, Alexander; Gómez-Cuadrado, Laura; Canel, Marta; Muir, Morwenna; Ring, Jennifer E; Maniati, Eleni; Sims, Andrew H; Pachter, Jonathan A; Brunton, Valerie G; Gilbert, Nick; Anderton, Stephen M; Nibbs, Robert J B; Frame, Margaret C

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

ADF和Cofilin1控制肌动蛋白应力纤维、核完整性和细胞存活

Kanellos, Georgios; Zhou, Jing; Patel, Hitesh; Ridgway, Rachel A; Huels, David; Gurniak, Christine B; Sandilands, Emma; Carragher, Neil O; Sansom, Owen J; Witke, Walter; Brunton, Valerie G; Frame, Margaret C

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy

p70S6K受黏着斑激酶调控,是Src选择性自噬所必需的。

Sandilands, Emma; Schoenherr, Christina; Frame, Margaret C