日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LINE-1 retrotransposition is a recurrent cause of MET exon 14 skipping in cancer

LINE-1逆转座是癌症中MET基因14号外显子跳跃的常见原因。

Karlow, Jennifer A; O'Connor, Callan; Sharaf, Radwa; Pavlick, Dean C; Savol, Andrej; Darcy, Christopher; Kakumanu, Akshay; Camara, William; Walsh, Matthew; Janovitz, Tyler; Kelley, Michael J; Serway, Christine N; Mitchell, Jerry; Elvin, Julia A; Montesion, Meagan; Burns, Kathleen H; Frampton, Garrett M

Cancer genomic profiling predicts pathogenicity of BRCA1 and BRCA2 variants

癌症基因组分析预测BRCA1和BRCA2变异的致病性

Kondrashova, Olga; Johnston, Rebecca L; Parsons, Michael T; Davidson, Aimee L; Canson, Daffodil M; Tran, Khoa A; Cline, Melissa S; Waddell, Nicola; Sivakumar, Smruthy; Sokol, Ethan S; Jin, Dexter X; Pavlick, Dean C; Decker, Brennan; Frampton, Garrett M; Spurdle, Amanda B

Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers

荟萃分析揭示了常见癌症中不同遗传祖先的体细胞改变存在差异

Amuzu, Setor; Xie, Amy X; Bai, Xuechun; Pekala, Kelly R; Pickersgill, Nicholas A; Ma, David; Perea-Chamblee, Tomin; Arora, Kanika; Chatila, Walid K; Derkach, Andriy; Shen, Ronglai; Frampton, Garrett M; Berger, Michael; Schultz, Nikolaus; Newberg, Justin Y; Carrot-Zhang, Jian

A Concordance Study among 26 NGS Laboratories Participating in the NCI Molecular Analysis for Therapy Choice Clinical Trial

参与NCI分子分析治疗选择临床试验的26家NGS实验室的一致性研究

Zane, Linda K; Yee, Laura M; Chang, Ting-Chia; Sklar, Jeffrey; Yang, Guangxiao; Wen, Jia Di; Li, Peining; Harrington, Robin; Sims, David J; Harper, Kneshay; Trent, Jeffrey M; LoBello, Janine R; Szelinger, Szabolcs; Benson, Kasey; Zeng, Jia; Poorman, Kelsey; Xu, Danbin; Frampton, Garrett M; Pavlick, Dean C; Miller, Vincent A; Tandon, Bevan; Swat, Wojciech; Weiss, Lawrence; Funari, Vincent Anthony; Conroy, Jeffrey M; Prescott, James L; Chandra, Pranil K; Ma, Charles; Champion, Kristen J; Baschkopf, Gregory X; Fesko, Yuri A; Freitas, Tracey Allen K; Tomlins, Scott A; Hovelson, Daniel H; White, Kevin; Sorrells, Shelly; Tell, Robert; Beaubier, Nike; King, David; Li, Lei; Kelly, Kevin; Uvalic, Jasmina; Meyers, Bridgette; Kolhe, Ravindra; Lindeman, Neal I; Baltay, Michele; Sholl, Lynette M; Lopategui, Jean; Vail, Eric; Zhang, Wenjuan; Telatar, Milhan; Afkhami, Michelle; Hsiao, Susan J; Mansukhani, Mahesh M; Adams, Emily; Jiang, LiQun; Aldape, Kenneth D; Raffeld, Mark; Xi, Liqiang; Stehr, Henning; Segal, Jeremy P; Aisner, Dara L; Davies, Kurtis D; Brown, Noah A; Livingston, Robert J; Konnick, Eric Q; Song, Wei; Solomon, James P; Walther, Zenta; McShane, Lisa M; Harris, Lyndsay N; Chen, Alice P; Tsongalis, Gregory J; Hamilton, Stanley R; Flaherty, Keith T; O'Dwyer, Peter J; Conley, Barbara A; Patton, David R; Iafrate, A John; Williams, P Mickey; Tricoli, James V; Karlovich, Chris

Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction

对 30 万个肿瘤进行基于组织的基因组分析,突显了低等位基因频率变异的检测。

Sisoudiya, Saumya D; Tukachinsky, Hanna; Keller-Evans, Rachel B; Schrock, Alexa B; Huang, Richard S P; Gjoerup, Ole; Pishvaian, Michael J; Shroff, Rachna; Sokol, Ethan S; Dennis, Lucas; Frampton, Garrett M; Sivakumar, Smruthy

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

U2AF1 突变可挽救 KRAS 突变引起的有害外显子跳跃

Walter David M, Cho Katherine, Sivakumar Smruthy, Lee Iris T-H, Dohlman Anders B, Shurberg Ethan, Jiang Kevin X, Gupta Akansha A, Frampton Garrett M, Meyerson Matthew

Understanding variants of unknown significance and classification of genomic alterations

了解意义不明的变异和基因组改变的分类

Pavlick, Dean C; Frampton, Garrett M; Ross, Jeffrey R

Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers

对非洲裔人群肿瘤进行测序,揭示了常见癌症中具有临床意义的基因改变存在差异。

Jiagge, Evelyn; Jin, Dexter X; Newberg, Justin Y; Perea-Chamblee, Tomin; Pekala, Kelly R; Fong, Christopher; Waters, Michele; Ma, David; Dei-Adomakoh, Yvonne; Erb, Gilles; Arora, Kanika S; Maund, Sophia L; Njiraini, Njoki; Ntekim, Atara; Kim, Susie; Bai, Xuechun; Thomas, Marlene; van Eeden, Ronwyn; Hegde, Priti; Jee, Justin; Chakravarty, Debyani; Schultz, Nikolaus; Berger, Michael F; Frampton, Garrett M; Sokol, Ethan S; Carrot-Zhang, Jian

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects.

HER2 突变的计算和功能分析揭示了变构激活机制和改变的药理效应

Ishiyama Noboru, O'Connor Matthew, Salomatov Andrei, Romashko Darlene, Thakur Shalabh, Mentes Ahmet, Hopkins Julia F, Frampton Garrett M, Albacker Lee A, Kohlmann Anna, Roberts Christopher, Buck Elizabeth

Homologous Recombination Deficiency Landscape of Breast Cancers and Real-World Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Patients With Somatic BRCA1/2, Germline PALB2, or Homologous Recombination Deficiency Signature

乳腺癌同源重组缺陷图谱及聚ADP核糖聚合酶抑制剂在具有体细胞BRCA1/2、种系PALB2或同源重组缺陷特征的患者中的真实世界疗效

Batalini, Felipe; Madison, Russell W; Sokol, Ethan S; Jin, Dexter X; Chen, Kuei-Ting; Decker, Brennan; Pavlick, Dean C; Frampton, Garrett M; Wulf, Gerburg M; Garber, Judy E; Oxnard, Geoffrey; Schrock, Alexa B; Tung, Nadine M