日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid

宿主蛋白环孢亲和素A通过降低病毒衣壳的弹性来限制HIV-1突变体进入细胞核。

Hong, Jun; Deshpande, Akshay; Thakare, Yatish; Simonovsky, Lora; Douglas, AidanDarian W; Guinness, Conall Mc; Rotem-Dai, Noa; Kortyna, Michelle L; Klarhof, J Ole; Shi, Jiong; James, Leo C; Boecking, Till; Francis, Ashwanth C; Rousso, Itay; Aiken, Christopher

Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV-1 Capsid.

利用时间分辨荧光成像和相关冷冻电镜断层扫描技术研究 HIV-1 衣壳的结构变化

Rodriguez Zaida K, Andino-Moncada Jonathan R, Buth Sergey A, Mehrani Atousa, Ranaweera Ahinsa, Shi Jincheng, Andrade Leonardo R, Singh Satya Prakash, Strutzenberg Timothy S, Marin Mariana, Guerrero-Ferreira Ricardo, Rahmani Hamid, Grotjahn Danielle A, Stagg Scott, Melikyan Gregory B, Lyumkis Dmitry, Francis Ashwanth C

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.

lenacapavir 高效抑制 HIV-1 成熟的主要机制

Huang Szu-Wei, Briganti Lorenzo, Annamalai Arun S, Greenwood Juliet, Shkriabai Nikoloz, Haney Reed, Armstrong Michael L, Wempe Michael F, Singh Satya Prakash, Francis Ashwanth C, Engelman Alan N, Kvaratskhelia Mamuka

Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir.

M66I衣壳变体对lenacapavir产生耐药性的结构和机制基础

Briganti Lorenzo, Annamalai Arun S, Bester Stephanie M, Wei Guochao, Andino-Moncada Jonathan R, Singh Satya P, Kleinpeter Alex B, Tripathi Meghna, Nguyen Binh, Radhakrishnan Rajalingam, Singh Parmit K, Greenwood Juliet, Schope Lauren I, Haney Reed, Huang Szu-Wei, Freed Eric O, Engelman Alan N, Francis Ashwanth C, Kvaratskhelia Mamuka

Structural, biophysical, and virological mechanistic characterization of HIV-1 capsid-targeting antivirals

HIV-1衣壳靶向抗病毒药物的结构、生物物理和病毒学机制表征

Kirby, Karen A; McFadden, William M; Wang, Lei; Du, Haijuan; Zhang, Huanchun; Castaner, Andres Emanuelli; Lorson, Zachary C; Nafisi, Arvin; Luchsinger, Charlotte; Hachiya, Atsuko; Cilento, Maria E; Snyder, Alexa A; Ravichandran, Shreya M; Cai, Xinyong; Tedbury, Philip R; Francis, Ashwanth C; Melikyan, Gregory B; Diaz-Griffero, Felipe; Wang, Zhengqiang; Sarafianos, Stefan G

The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity

宿主蛋白亲环蛋白A通过降低衣壳弹性来抑制HIV-1进入细胞核。

Hong, Jun; Deshpande, Akshay; Thakare, Yatish; Simonovsky, Lora; Douglas, AidanDarian W; Mc Guinness, Conall; Rotem-Dai, Noa; Kortyna, Michelle L; Klarhof, J Ole; Shi, Jiong; Boecking, Till; James, Leo C; Francis, Ashwanth C; Rousso, Itay; Aiken, Christopher

Elasticity of the HIV-1 core facilitates nuclear entry and infection

HIV-1核心的弹性有利于病毒进入细胞核并引发感染。

Deshpande, Akshay; Bryer, Alexander J; Andino-Moncada, Jonathan R; Shi, Jiong; Hong, Jun; Torres, Cameron; Harel, Shimon; Francis, Ashwanth C; Perilla, Juan R; Aiken, Christopher; Rousso, Itay

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

利用突变型 HIV-1 衣壳蛋白进行的多项多学科研究揭示了晶格稳定的结构机制

Gres, Anna T; Kirby, Karen A; McFadden, William M; Du, Haijuan; Liu, Dandan; Xu, Chaoyi; Bryer, Alexander J; Perilla, Juan R; Shi, Jiong; Aiken, Christopher; Fu, Xiaofeng; Zhang, Peijun; Francis, Ashwanth C; Melikyan, Gregory B; Sarafianos, Stefan G

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

强效HIV-1衣壳抑制剂的结构和机制基础

Bester, Stephanie M; Wei, Guochao; Zhao, Haiyan; Adu-Ampratwum, Daniel; Iqbal, Naseer; Courouble, Valentine V; Francis, Ashwanth C; Annamalai, Arun S; Singh, Parmit K; Shkriabai, Nikoloz; Van Blerkom, Peter; Morrison, James; Poeschla, Eric M; Engelman, Alan N; Melikyan, Gregory B; Griffin, Patrick R; Fuchs, James R; Asturias, Francisco J; Kvaratskhelia, Mamuka

Facile autofluorescence suppression enabling tracking of single viruses in live cells

简便的自发荧光抑制方法可实现对活细胞中单个病毒的追踪

Chen, Yen-Cheng; Sood, Chetan; Francis, Ashwanth C; Melikyan, Gregory B; Dickson, Robert M